Publications

Here are members of our team featured in the PubMed publication database:

Faculty:

Lab Personnel:

Selected Publications

Perl, A, Gonzalez-Cabello, R., Lang, I. and Gergely P. (1982) Depressed natural and lectin-dependent cell-mediated cytotoxicity against adherent HEp-2 cells in patients with systemic lupus erythematosus. Immunol. Comm. 11, 431-440.

Perl, A., J.D. Rosenblatt, I.S.Y. Chen, J.P. DiVincenzo, R. Bever , B.J. Poiesz, and G.N. Abraham (1989) Detection and cloning of new HTLV-related sequences in man. Nucleic Acids Res., 17, 6841-6854.

Perl, A., Isaacs, C.M., Eddy, R.L., Byers, M.G.,and Shows, T.B. (1991) The human T-cell leukemia virus-related endogenous sequence (HRES-1) is located on chromosome 1 at q42. Genomics, 11, 1172-1173.

Banki, K., J.S. Maceda, E. Hurley, E. Ablonczy, D. Mattson, L. Szegedy, C. Hung, and A. Perl (1992) HRES-1, a human endogenous retroviral sequence encodes a 28 kd protein: a possible autoantigen for HTLV gag-reactive autoantibodies. Proc. Natl. Acad. Sci. USA, 89, 1939-1943.

Krieg, A.M., Gourley, M.F. and Perl, A. (1992) Endogenous retroviruses: Potential etiologic agents in autoimmunity. FASEB J.6:2537-2544.

Srivastava, B.I.S., K. Banki & A. Perl (1992) Detection of human T-cell lymphotropic virus type I or a related retrovirus in patients with mycosis fungoides, Sezary syndrome and Kaposi sarcoma. Cancer Res. 52, 4391-4395.

Krieg, A.M., Gourley, M.F., Klinman, D.M., Perl, A.,and Steinberg, A.D. (1992) Heterogenous expression and induction of human endogenous retroviral sequences in peripheral blood mononuclear cells from patients with polymyositis and controls. AIDS Res. Hum. Retrovirus. 12, 1991-1998.

Perl, A. and Banki, K. (1993) Human endogenous retroviral elements and autoimmunity: data and concepts. Trends Microbiol. 1:153-156.

Agarwal, R.K. and Perl, A. (1993) PCR amplification of highly GC-rich DNA template after denaturation by NaOH. Nucleic Acids Res. 21, 5283-5284.

Banki, K., É. Ablonczy, M. Nakamura, and Perl, A. (1994) Effect of the p40/tax transactivator of human T-cell lymphotropic virus type I (HTLV-I) on expression of autoantigens. AIDS Res. Hum. Retrovirus 10:303-308.

Banki, K., Halladay, D. and Perl, A. (1994) Cloning and Expression of the Human Gene for Transaldolase: a Novel Highly Repetitive Element Constitutes an Integral Part of the Coding Sequence. J. Biol. Chem. 269:2847-2851.

Banki, K., E. Colombo, F. Sia, D. Halladay, D. H. Mattson, A.H. Tatum, P.T. Massa, P.E. Phillips, Perl, A. (1994) Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis. J. Exp. Med. 180:1649-1663.

Perl, A., Colombo, E., Dai, H., Agarwal, R.K., Mark, K., Banki, K., Poiesz, B.J., Phillips, P.E., Hoch, S.O., Reveille, J.D. and Arnett, F.C. (1995). Antibody reactivity to the HRES-1 endogenous retroviral element identifies a subset of patients with systemic lupus erythematosus and overlap syndromes: Correlation with antinuclear antibodies and HLA class II alleles. Arth. Rheum. 38: 1660-1671.

Banki, K. and Perl, A. (1996) Inhibition of the catalytic activity of human transaldolase by antibodies and site-directed mutagenesis. FEBS Lett. 378: 161-165.

Banki, K., Hutter, E., Colombo, E., Gonchoroff, N.J. and Perl, A. (1996) Glutathione levels and sensitivity to apoptosis are regulated by changes in transaldolase expression. J. Biol. Chem. 271: 32994-33001.

Colombo, E., Banki, K., Tatum, A.H., Daucher, J., Ferrante, P., Murray, R.S., Phillips, P.E. and Perl, A. (1997) Comparative analysis of antibody and cell-mediated autoimmunity to transaldolase and myelin basic protein in patients with multiple sclerosis. J. Clin. Invest.99:1238-1250.

Banki, K., Eddy, R.L., Shows, T.B., Halladay, D.L., Bullrich, F., Croce, C.M., Jurecic, V., Baldini, A. and Perl, A. (1997) The human transaldolase gene is located on chromosome 11 at p15.4-p15.5. Genomics, 45: 233-238.

Banki, K., Hutter, E., Gonchoroff, N.J. and Perl, A. (1998) Molecular ordering in HIV-induced apoptosis: oxidative stress, activation of caspases and cell survival are regulated by transaldolase. J. Biol. Chem. 273:11944-11953.

Perl, A. (1999) Editorial. Mechanisms of viral pathogenesis in rheumatic diseases. Ann. Rheum. Dis. 58:454-461.
Magistrelli, C., Samoilova, E., Agarwal, R.K., Banki, K., Ferrante, P., Vladutiu, A., Phillips, P.E. and Perl, A. (1999) Polymorphic genotypes of the HRES-1 human endogenous retrovirus locus are associated with systemic lupus erythematosus and autoreactivity. Immunogenetics, 49:829-834.

Banki, K., Hutter, E., Gonchoroff, N.J. and Perl, A. (1999) Elevation of mitochondrial transmembrane potential and ROI levels are early events and independent from activation of caspases in Fas signaling. J. Immunol. 162:1466-1479.

Esposito, M., Venkatesh, V., Otvos, L., Weng, Z., Vajda, S., Banki, K. and Perl, A. (1999) Human transaldolase and cross-reactive viral epitopes identified by autoantibodies of multiple sclerosis patients. J. Immunol. 163:4027-4032.

Puskas, F., Gergely, P. Jr., Banki, K. and Perl, A. (2000) Stimulation of the pentose phosphate pathway and glutathione levels by dehydroascorbate, the oxidized form of vitamin C. FASEB J.14: 1352-1361.

Perl, A., Colombo, E., Samoilova, E., Butler, M.C. and Banki. K. (2000) Human transaldolase-associated repetitive elements are transcribed by RNA polymerase III. J. Biol. Chem. 275: 7261-7272.

Perl, A. (2001) Editorial: Endogenous Retroviruses in Pathogenesis of Autoimmunity. J. Rheumatol. 28:461-464.

Gergely, P. Jr., Grossman, C., Niland, B., Puskas, F., Neupane, H., Allam, F., Banki, K., Phillips, P.E. and Perl, A. (2002) Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus. Arth. Rheum. 46:175-190.

Puskas, F., Gergely, P., Niland, B., Banki, K. and Perl, A. (2002) Differential regulation of hydrogen peroxide and Fas-dependent apoptosis pathways by dehydroascorbate, the oxidized form of vitamin C. Antiox. Redox Signal. 4:357-369.

Perl, A, Gergely, P., Puskas, F. and Banki, K. (2002) Metabolic switches of T cell activation and apoptosis. Antiox. Redox Signal. 4:427-443.

Kammer, G.M., Perl, A., Richardson, B.C., Tsokos, G.C. (2002) Abnormal T cell signal transduction in systemic lupus erythematosus. Arth. Rheum. 46:1139-1154.

Gergely, P. Jr., Niland, B., Gonchoroff, N., Pullmann, R. Jr., Phillips, P.E. and Perl, A.(2002) Persistent mitochondrial hyperpolarization, increased reactive oxygen intermediate production, and cytoplasmic alkalinization characterize altered IL-10 signaling in patients with systemic lupus erythematosus. J. Immunol. 169:1092-1101.

Nagy, G, Koncz, A. and Perl A (2003) T cell activation-induced mitochondrial hyperpolarization is mediated by Ca2+- and redox-dependent production of nitric oxide. J. Immunol. 171:5188-5197.

Perl,A.; Gergely,P.,Jr. and Banki,K. (2004) Mitochondrial dysfunction in T cells of patients with systemic lupus erythematosus. Int. Rev. Immunol. 23:293-313.

Grossman, C. E., Qian, Y., Banki, K., Perl, A. (2004) ZNF143 mediates basal and tissue-specific expression of human transaldolase. J. Biol. Chem. 279: 12190-12205.

Perl, A., Gergely, P. Jr., Nagy, G., Koncz, A., and Banki, K. (2004). Mitochondrial hyperpolarization: a checkpoint of T-cell life, death, and autoimmunity. Trends Immunol. 25:360-367.

Grossman, C. E., Niland, B., Stancato, C, Verhoeven, N.M., van der Knaap, M.S., Jakobs, C., Brown, L.M., Vajda, S., Banki, K. and Perl, A. (2004) Deletion of serine 171 causes inactivation, proteasome-mediated degradation and complete deficiency of human transaldolase. Biochem. J. 382:725-231.

Nagy, Gy, Barcza. M., Gonchoroff, N., Phillips, P.E. and Perl, A. (2004) Nitric oxide-dependent mitochondrial biogenesis generates Ca2+ signaling profile of lupus T cells. J. Immunol. 173:3676-3683.

Nagy, Gy, Koncz, A, Phillips, P.E. and Perl, A. (2005) Mitochondrial signal transduction abnormalities in systemic lupus erythematosus. Curr. Immunol. Rev. 1: 61-67.

Gergely. P. Jr, Pullmann, R., Stancato, C., Otvos, L. Jr, Koncz, A., Blazsek, A., Poor, Gy, Brown, K.E., Phillips, P.E. and Andras Perl. (2005) Increased prevalence of transfusion-transmitted virus and cross-reactivity with immunodominant epitopes of the HRES-1/p28 endogenous retroviral autoantigen in patients with systemic lupus erythematosus. Clin. Immunol. 116: 124-134.

Nagy, Gy, Koncz, A, and Perl, A. (2005) T- and B-cell abnormalities in systemic lupus erythematosus. Crit. Rev. Immunol. 25: 123-140.

Niland, B., Banki, K., Biddison, W.E. and Perl, A. (2005) CD8+ T cell-mediated HLA-A*0201-restricted cytotoxicity to transaldolase peptide 168-176 in patients with multiple sclerosis. J. Immunol. 175:8365-8378.

Nagy G.and Perl, A. (2006) The role of nitric oxide in abnormal T cell signal transduction in systemic lupus erythematosus. Clin. Immunol. 118: 145-151.

Vas, Gy., Conkrite, K., Amidon, W., Qian, Y., Banki, K., and Perl, A. (2006) Study of transaldolase deficiency in urine samples by LC-MS/MS. J. Mass Spec. 41:463-469.

Perl, A., Qian, Y, Chohan, K.R., Shirley, C.R., Amidon, W., Banerjee, S., Middleton, F.A., Conkrite, K.L., Barcza, M., Gonchoroff, N., Suarez, S.S., and Banki, K.(2006) Transaldolase is essential for maintenance of the mitochondrial transmembrane potential and fertility of spermatozoa. Proc. Natl. Acad. Sci USA 103: 14813-14818.

Fernandez, D., Bonilla, E., Mirza, N, Niland, B. and Perl, A. (2006) Rapamycin reduces disease activity and normalizes T-cell activation-induced calcium fluxing in patients with systemic lupus erythematosus. Arth. Rheum. 54: 2983-2988.

Nagy, G., Ward, J., Mosser, D.D., Koncz, A., Gergely, P.Jr., Stancato, S., Qian, Y, Fernandez, D., Niland, B., Grossman, C.E., Telarico, T, Banki, K, Perl, A. (2006) Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection. J. Biol. Chem. 281: 34574-34591 External Icon

Fernandez, D., Bonilla, Phillips, P.E. and Perl, A. (2006) Signaling abnormalities in systemic lupus erythematosus as potential drug targets. Endocrin, Metabolic & Immune Disorders - Drug Targets. 6: 305-311.

Book Chapters

Perl, A. (2000) Viruses in rheumatic diseases. In Molecular Rheumatology. Ed. Tsokos, G.C.; Humana Press, pp. 15-33.

Inman, R.D., Perl, A., and Phillips, P.E. (2001) Infectious agents in chronic rheumatic diseases. In: Arthritis and Allied Conditions. A Textbook of Rheumatology, 14th edition. Ed. Koopman, W.J. Lea & Febiger, Philadelphia - London, pp. 635-661.

Perl, A. (2003) Role of Endogenous Retroviruses in Autoimmune Diseases. Rheum. Dis. Clin. North Am. 29: 123-143.

Perl, A. and Gergely, P., Jr. (2003). Mitochondrial signaling abnormalities in T cells of patients with systemic lupus erythematosus. In: Frontiers in Autoimmunity: Fundamental Aspects and Clinical Perspectives.

Ed. M. Zouali. IOS Press, Amsterdam, pp.217-241.

Perl, A. (2004). Editor: Autoimmunity. Methods and Protocols. In Methods in Molecular Medicine series. Humana Press, Totowa, NJ.

Perl, A. (2004) Pathogenesis and Spectrum of Autoimmunity. In: Autoimmunity. Methods and Protocols. Ed. Perl, A.Humana Press, Totowa, N.J. pp. 1-8.

Perl, A., Nagy, G, Gergely, P.Jr., Puskas, F., Qian, Y. and Banki, K. (2004). Apoptosis and mitochondrial dysfunction in lymphocytes of patients with systemic lupus erythematosus. In: Autoimmunity. Methods and Protocols. Ed. Perl, A. Humana Press, Totowa, N.J. pp. 87-114.
Niland, B. and Perl, A. (2004) Evaluation of Autoimmunity to Transaldolase in Multiple Sclerosis. In: Autoimmunity. Methods and Protocols. Ed. Perl, A. Humana Press, Totowa, N.J. pp. 155-171.
Inman, R.D., and Perl, A. (2005) Infectious agents in chronic rheumatic diseases. In: Arthritis and Allied Conditions. A Textbook of Rheumatology, 15th edition. Ed. Koopman, W.J. Lea & Febiger, Philadelphia - London, 647-677.

Perl, A. (2005) Regulation of the pentose phosphate pathway and its impact on apoptosis under physiological and disease conditions. In. Clinical and Molecular Aspects of Defects in Creatine and Polyol Metabolism. Eds: C. Jakobs and S. Stockler-Ipsiroglu. SPS Publications, Heilbronn, Germany. pp: 122-138.

Perl, A. (2006) Mitochondrial Dysfunction and Oxidative Stress in T cells of Patients with SLE. In. Systemic Lupus Erythematosus(eds. Tsokos, G.C., Gordon, and Smolen, J). In press.

For Complete Listing of Andras Perl's Publications, go to PubMed External Icon