Rosemary Rochford, PhD, Vice President for Research
Research at Upstate
is guided by four disease- based pillars that stimulate cross-departmental collaboration and inter- disciplinary
research. Our researchers are based in departments, but their work can also be thought of in the context of the pillars or in
the basic sciences.
Office of Vice President for Research
Allen E Silverstone, PhD
766 Irving Ave.
Syracuse, NY 13210
315 464-5440
Current Appointments
- Professor of Microbiology and Immunology
- Professor of Pharmacology
Hospital Campus
- Downtown
Research Programs and Affiliations
- Biomedical Sciences Program
- Cancer Research Institute
- Microbiology and Immunology
- Research Pillars
Education & Fellowships
- Postdoctoral Fellow: MIT Cancer Center, 1978, Leukemia & Immunology
- PhD: Massachusetts Institute of Technology, 1970
Research Interests
- How dioxins and estrogens and estrogenic compounds affect the immune system.
Research Abstract
My program explores how dioxins, PCBs, and estrogenic compounds affect the immune system at the cellular and molecular level. We are using a combination of dioxin receptor (AhR) knock out and conditional knock out mice, Estrogen receptor knock-out mice (ER alpha and beta) and microarrays to identify the specific gene programs activated by these agents in the earliest developing T and B cells. Selected ReferencesLaoisa, MD,A Wyman,FG Murante, NC Fiore, JE Staples, TA Gasiewicz, AE Silverstone (2003) Cell Proliferation arrest within intrathymic lymphocyte progenitor cells causes thymic atrophy mediated by the aryl hydrocarbon receptor: J. Immunol. 171, 4582-4591.
Laiosa,MD, Z-W Lai, TS Thurmond, NC Fiore, C DeRossi, BC. Holdener, TA. Gasiewicz, and AE Silverstone. 2,3,7,8-Tetrachlorodibenzo-p-dioxin Causes Alterations in Lymphocyte Development and Thymic Atrophy in Hemopoietic Chimeras Generated from Mice Deficient in ARNT2,Tox. Sci. 2002, 69,117-124