Vascular disease, Vascular Complications in Diabetes, Endothelial and Smooth Muscle Intracellular Signaling
Injury prevention; Designer drug use; Automotive safety
Micro-mechanics of implant interfaces; damage evolution of joint replacements and biomaterials; in vivo models of tumor osteolysis and prediction of fracture risk; general orthopedic biomechanics.
Pharmacology, Toxicology, Pharmacokinetics
Regulation of innate immune responses to viruses.
Role of glycoproteins in oncogenesis and brain development
Epidemiology/pharmacotherapy of schizophrenia; Ego strength among inpatients & its relation to engagement in treatment; cardiovascular risk factors in patients with serious mental illness; changes in cognition in response to depression treatment
Clinical reasearch in various Neuro-Ophthalmic conditions such as idiopathic intracranial hypertension; as well as multiple sclerosis and headache syndromes.
Smoking and alcohol use disorders commonly occur together. People who drink alcohol are three times more likely to smoke, and smokers are four times more likely than the general population to be dependent on alcohol. When nicotine and alcohol dependence occur together, the health risks are increased, and the chances of quitting smoking and drinking are lower. The exact mechanism of co-occurring nicotine and alcohol dependence is not clearly understood. In everyday clinical practice, interventions used for smoking cessation are not combined with treatment of alcohol dependence. Our clinical research program is focused on developing new medications to treat alcohol and nicotine dependence simultaneously. Two investigational new drugs recently tested at our division decreased drinking and/or smoking severity and prevented cognitive problems associated with smoking and drinking. Our goal is to establish the safety and efficacy of these neuroprotective agents in different patient populations. Preventing cognitive decline is of great importance to inpatients with addiction. Development of new, neuroprotective medications may reduce harm associated with heavy smoking and alcohol use.
Molecular basis of cortical-basal ganglia and cortical-cerebellar circuit formation and dysfunction in neurological and psychiatric disease.
Multiple sclerosis and general neurology.
Motor fluctuations and non-motor problems of Parkinson's disease; surgical treatment of Parkinson's disease and other movement disorders; experimental therapies for Parkinson's disease
Use of standardized patient examinations to promote student development and the development of clinical instructors' teaching skills; development of professional behaviors.
Regulation of ciliary dynein activity and assembly, and the role of the central pair complex in ciliary motility regulation.
Varicella zoster pathogenesis.
Post-translational regulation of the Hsp90 molecular chaperone machinery in cancer
Health Disparities, Medical Sociology, Med Education, Ethics, Research Methods, Behavioral Health, Genetics
Management of the pediatric airway. Current research: Pharangeal tears in children due to child abuse, cricoid injury and reconstruction.
Visual Neurophysiology; Visual Attention; Visual Search Behavior