Gastroesophogeal Reflux Disease. Bravo pH Analysis. Cyclic Vomiting Syndrome. Anti IL5 Reslizumab in the treatment of Eosinophilic Esophagitis, a National Study in progress. Safety and efficacy of infliximab use in children and adolescents.
Computed Tomographic Angiography, Magnetic Resonance Angiography, Interventional Oncology, Hypertension
My lab studies brain development and brain function in individuals with genetic disorders. The main focus of our work is on a genetic disorder called 22q11.2 Deletion Syndrome (22q11DS). Individuals with 22q11DS are at a 25-fold greater risk for developing schizophrenia than individuals in the general population. We examine the effects of genetic mutation, brain development, and neuropsychological function in youth with this disorder, in order to identify the factors that place youth at highest risk for developing schizophrenia. Eventually, our research may allow us to identify and provide early interventions to youth at high risk for schizophrenia, potentially easing the huge toll that schizophrenia takes on families. Another focus of our work is to determine the effectiveness of computer-based, on-line, cognitive interventions in youth with genetically based intellectual disorders. Our hope is that by demonstrating the effectiveness of on-line, cognitive interventions, we can reach and benefit many youth who may not have access to centers that are providing such interventions in person.
Mechanisms by which regulatory T cells restrain helper T cell-mediated immune response in SLE.
Third World ENT Disease and Training Programs for Providers
Treatment of pediatric brain tumors.
Improving feedback to and evaluations of pediatric residents.
RNA polymerase I transcription (structure, assembly, regulation), nucleolar biology, macromolecular architecture, crosslinking, proteomics, bioinformatics, modeling, molecular genetics, biochemistry, model systems
Cancer biology, cell signaling, the role of actin cytoskeleton in tumor progression, mouse models of cancer
Coronary artery disease; Acute coronary syndromes; Acute myocardial infarction; Interventional cardiology; Coronary angioplasty/stenting
Advanced tomographic reconstruction in PET and SPECT. Breast cancer detection and imaging using molecular, MR and x-ray imaging. Nonrigid multimodality breast image registration and fusion. Advanced breast cancer lumpectomy. Ultrafast laser-based x-ray source for biomedical imaging. Advanced tomographic reconstruction in cone-beam micro-CT.