Associate Professor, Pharmacology
Postdoctoral positions are available in the areas of: (1) biological and biochemical studies of CXCR4 mediated stem-cell migration and beta-catenin mediated stem-cell proliferation/apoptosis; (2) bioengineering of regenerated 3D micro bone marrow induced by nanoscaffolds; and (3) discovery and development of new drugs to target CXCR4 and beta-catenin. We are seeking self-motivated and diligent PhD. and/or MD researchers. Multidisciplinary training in biochemistry, cell and molecular biology, bioengineering and target-based drug discovery would be an advantage. Please send your curriculum vitae and the contact information of three references to: Dr. An via e-mail: email@example.com
Associate Professor, Ophthalmology
The Calvert lab at SUNY Upstate Medical University seeks a talented postdoctoral researcher to join a dynamic group within the Center for Vision Research. We study the function of the retina at the molecular and cellular levels as well as the underpinnings of degenerative diseases. Our approaches center on live cell multiphoton and confocal imaging of protein motion and interactions, including fluorescence relaxation after photoconversion, fluorescence lifetime imaging, and fluorescence cross correlation spectroscopy (e.g. see Najafi, Maza and Calvert, 2012, PNAS, 109:203-208; Najafi et al., 2012, J. Gen. Phys., 140:249-266). A new initiative is the implementation of STED microscopy to obtain super-resolution live cell structural information at near protein spatial resolution. Candidates must hold a PhD in biochemistry/molecular biology, neuroscience/physiology, biophysics or related fields. Preference will be given to candidates that have demonstrated capabilities with optical systems and imaging data processing or that have significant experience in multiphoton fluorescence microscopy. Significant knowledge of Matlab (or R) and LabView are pluses. The successful candidate will work within the rich environment of the SUNY Upstate Center for Vision Research (http://www.centervisionresearch.org/) and will be a member in training of the multi campus SUNY Eye Institute (http://www.sunyeye.org/). The Center for Vision Research resides in the newly opened (as of March 2014) Neuroscience Research Building which also houses the Department of Neuroscience and Physiology. Both departments have a focus on advanced fluorescence imaging of the nervous system.
Interested individuals should submit a cover letter outlining research accomplishments, a CV and the names and contact information of 3 references to Dr. Peter D. Calvert, PhD, Associate Professor of Ophthalmology and the Center for Vision Research, SUNY Upstate Medical University, Syracuse, NY 13210. Email: firstname.lastname@example.org. Web: http://www.centervisionresearch.org/Investigators/Peter-D.-Calvert-Ph.D.
Assistant Professor, Microbiology and Immunology
Highly motivated candidate with a PhD degree (or equivalent) in a relevant scientific discipline, including microbiology, molecular biology, immunology, and/or cell biology, is required. Experience with viral and mammalian cell culture is preferred but not a prerequisite. A strong record of scientific excellence as evidenced by publications in peer-reviewed scientific journals is a plus.
The successful candidate for this postdoctoral position will work independently on projects related to human cytomegalovirus (HCMV) pathogenesis. The project will be focused on the cellular signaling pathways induced during HCMV entry and how these signals promote virus entry into monocytes while concurrently stimulating the survival of these short-lived cells. The postdoc will be expected to publish on these topics and assist in obtaining funding. The postdoc will also be expected to help develop new avenues of research related to the mission of the lab.
Gary Chan, PhD
Associate Professor, Emergency Medicine
EMS Medicine Fellowship: Currently accepting applications for our ACGME-accredited EMS Medicine Fellowship program. Contact Lisa Williams, Program Coordinator, with interest (email@example.com) (315) 464-4851.
Assistant Professor, Biochemistry and Molecular Biology
This position is for a postdoc to participate in grant-funded research on chromosomal DNA replication and genomic instability. We are interested in the mechanisms of replication stress-induced single-stranded DNA and chromosome breakage formation in the genomes of both the model organism budding yeast and human. Current projects include but are not limited to: 1) characterizing the structural components of the replisome during replication stress using Mass Specrometry; 2) investigating the mechanism of single-stranded DNA formation in replication checkpoint mutants using microarray analysis; and 3) mapping origins of replication and chromosome fragile sites in the human genome using next-generation sequencing. If interested, please contact me by email at FengW@upstate.edu
Professor, Biochemistry and Molecular Biology
Postdoctoral Position in Developmental Genetics / non-coding RNAs. The laboratory is studying translational control of gene expression during embryonic development. This focus is on a long non-coding RNA called 7SK-RNA, and the RNA methyltransferase (Bin3/MePCE) that regulates its stability. The Bin3-7SK-RNA complex is required for Bicoid-dependent repression of caudal mRNA translation in early embryos (Singh et al. Dev. Biol 352,104; Cosgrove et al., WIRES RNA [Wiley], July 2012). Project will use high-throughput methods to identify new Bin3 targets and mechanisms in combination with Drosophila genetics, molecular biology and biochemistry. Candidate must have at least 2 years of experience with modern Drosophila genetics.
None at present.
Professor, Microbiology and Immunology
Post-doctoral positions available in the laboratory of William G. Kerr, Ph.D. (Depts. of Microbiology & Immunology and Pediatrics, SUNY Upstate). Candidates are sought for ongoing NIH funded projects concerning the role of inositol phospholipid signaling in: (1) hematologic and breast neoplasms [J. Immunology 184: 3582-3889 (2010)], (2) Crohn's disease and inflammatory bowel disease [ Gut 60: 177-88 (2011)] (3) immune regulation [ SCIENCE 295, 2094-2097 (2002), J. Immunology 176, 7165-69 (2006); Blood 113: 2934-44 (2009)] and (4) stem cell biology [BLOOD 98, 2028-2038 (2001); 107, 4338-45, 2006; 113: 2924-33 (2009)]. In addition to mechanistic studies devoted to the above questions, there is also significant potential for translational research and participation in commercial ventures. For further information or to apply, please contact William G. Kerr: firstname.lastname@example.org
Professor, Clinical Campus - Neurology
Endovascular Surgical Neuroradilogy Fellowship: Tow years fellowship dedicated towards obtaining clinical knowledge and technical skills in the diagnosis, decision macking, endovascular treatment and long-term followup of acute ischemic Stroke/intervention, extracranial and intracranial carotid, vertebral and basilar artery stenosis/angioplasty and stenting, embolization of cerebral aneurysm with or without stent, embolization of arteriovenous malformation (AVM), arteroivenous fistula (AVF) and brain tumor, treatment of cerebral vasospasm and delivery of pharmacological agents to the brain vascular beds.
Fellows will have an opportunities to participate in the clinical trials and clinical ourcome studies of stroke, aneurysms and vascular malformations
Associate Professor, Neuroscience and Physiology
09/10/12 Postdoctoral applications welcome - please contact email@example.com.
Interested applicant should send curriculum vitae and names, addresses, and telephone numbers of three references by e-mail to firstname.lastname@example.org
Brief Research Description
1. Genetic and Immunological impact of the HRES-1 endogenous retrovirus in Systemic Lupus Erythematosus
Genetic and environmental factors mediate the development of autoimmune diseases, such as systemic lupus erythematosus (SLE). We have identified polymorphic genotypes of the HRES-1 endogenous retrovirus, located on human chromosome 1 band q42, that influence autoimmunity in SLE. Inheritance of HRES-1 alleles in lupus families is investigated. Our recent data suggest that a small GTP-ase encoded by HRES-1, termed HRES-1/Rab4 influences the recycling of cell surface receptors, such as CD4 and the T-cell receptor zeta chain, and may contribute to abnormal T-cell activation in lupus by influencing T-cell synapse formation via receptor recycling.
2. Metabolic control of systemic autoimmunity
This project investigates the role of mitochondrial dysfunction in aberrant activation and death signal processing in lupus T cells. In particular, metabolic pathways affecting nitric oxide production, glutathione metabolism, and the mammalian target of rapamycin are being investigated.
3. Regulation of Autoimmunity & Tumorigenesis by Transaldolase via Metabolic Control of Programmed Cell Death
Defects of apoptosis, a form of programmed cell death, underlie the causation of cancer, and autoimmune diseases. We have discovered and molecularly cloned human transaldolase (TAL) as an autoantigen and metabolic regulator of apoptosis. TAL is highly expressed in oligodendrocytes of the brain which are selectively targeted by autoreactive T cells and antibodies in patients with multiple sclerosis. Presently, we analyze the impact of TAL deficiency in humans and knock-out mice developed in the laboratory.
Recent Publications (* denotes UMU student/trainee)
*Pullmann, R. Jr., *Bonilla, E., Phillips, P.E., Middleton, F.A. and Perl, A. (2008) Haplotypes of the HRES-1 endogenous retrovirus are associated with development and disease manifestations of systemic lupus erythematosus. Arth. Rheum. 58:532-540.
Vyshkina, T., Sylvester, A., Sadiq, S., *Bonilla, E., Canter, J., Perl, A. and Kalman, B.(2008) Association of Common Mitochondrial DNA Variants with Multiple Sclerosis and Systemic Lupus Erythematosus. Clin. Immunol. 129:31-35.
*Fernandez D.R. and Perl, A. (2009) Metabolic control of T-cell activation and death in SLE. Autoimmun. Rev. 8:184-189.
*Fernandez, D.R., *Telarico, T., *Bonilla, E., *Li, Q., *Banerjee, S., Middleton, F.A., Phillips, P.E., Crow, M.K., Oess, S., Muller-Esterl, W., and Perl, A. (2009) Activation of mTOR controls the loss of TCRζ in lupus T cells through HRES-1/Rab4-regulated lysosomal degradation. J. Immunol. 182: 2063-2073.
Hanczko, R., *Fernandez, D.R., *Doherty, E., Qian, Y., Vas, G., Niland, B., *Telarico, T., *Garba, A., Banerjee, S., Middleton, F.A., Barrett, D., Barcza, M., Banki, K., Landas, S.K. and Perl, A. (2009) Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine. J. Clin. Invest. 119:1546-1557.
*Niland, B, *Miklossy, G, Banki, K, Biddison, W.E., Casciola-Rosen, L., Rosen, A., Martinvalet, D., Lieberman, J., and Perl, A. (2010) Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients. J. Immunol., 184:4025-32.
Distinguished Professor, Cell and Developmental Biology
Postdoctoral postions are available. Please submit a letter of interest along with a copy of your CV and research experience/interests to Dr. Turner
Assistant Professor, Ophthalmology
A postdoctoral position is now open in the Viczian laboratory, which studies how pluripotent cells, like stem cells, develop and differentiate into retinal cone photoreceptor cells. The successful candidate will study the signaling pathways and molecular mechanisms that are necessary to form these sight-saving cells. They will have a PhD in biochemistry/molecular biology or neuroscience; a background in stem cell biology is preferred but those with mammalian cell culture experience will still be considered. The Viczian laboratory is one of three groups, which are working side-by-side to understand eye formation in three model organisms: fly, frog and mouse. We are part of a bigger group, the Center for Vision Research, which is the research arm of the Ophthalmology Department at Upstate Medical University. This opportunity will include training of the candidate so that they may pursue a future career as an independent PI. Candidates should send a current curriculum vitae, three references with contact information and a cover letter describing their interest in the project to email@example.com. Please include "Postdoc" in the subject of your email.
Assistant Professor, Neuroscience and Physiology
Postdoctoral positions are currently available. We are seeking candidates who have a background in electrophysiology with interests in neurobiology. If you are interested, please send your electronic CV (curriculum vitae) to Yunlei Yang (firstname.lastname@example.org).
1. Cover letter indicating current and future research interests and expected availability date
2. CV (Curriculum Vitae)
3. Description of past research experience and accomplishments
4. Selected reprints of publications
5. Names of three references
Associate Professor, Psychiatry and Behavioral Sciences
Postdoctoral positions are available to study molecular, cellular, and circuit mechanisms in the prefrontal cortex that regulate reward, executive, and social behavioral function as well as related mental diseases such as addiction, autism, and dementia. Prospective candidates will apply cellular electrophysiology, viral-mediated gene delivery, and optogenetic techniques in brain slices from transgenic mice deficient in emerging microRNA and other novel pathways that regulate synapse assembly, function, and plasticity. A Ph.D. and/or M.D. degree in related fields is required and prior experience in patch-clamp and/or intracellular recordings is highly desirable. Interested candidates should submit a curriculum vitae and contact information for three references to Dr. Wei-Dong Yao, State University of New York, Upstate Medical University, Syracuse, NY via email to email@example.com.
Associate Professor, Neurosurgery
A postdoctoral position for neuroscience/stem cell biology is available at the Department of Neurosurgery, State University of New York Upstate Medical University. We are looking for a postdoc with experience in both in vivo and in vitro to join our research team. Individuals who have experience in bone marrow stem cell/hematopoietic stem cell biology and pathology, vascular biology, neural stem cell biology, dendritic spine plasticity, molecular biology, flow cytometry, and live brain imaging are preferred. The methods to be used in experiments include making animal models for stroke and TBI, ICV injection, animal behavioral test, 2-photon live brain imaging, primary cell cultures of neurons, neural stem cells, bone marrow stem cells or vascular cells, gene modification and regulation, flow cytometry, Western blot, qRT-PCR, ELISA, and immunohistochemistry.
PhD degree in stem cell biology/Neuroscience/ Neurobiology with related publications is required for this position. Individuals who are interested in this position please send 1) your curriculum vitae and 2) the names and contact information of 3 references to apply for this position.
Please contact Dr. Li-Ru Zhao: firstname.lastname@example.org
Assistant Professor, Neuroscience and Physiology
Postdoc positions are available to study Drosophila neural stem cells. If interested, please contact Dr. Sijun Zhu at email@example.com.