Hemoglobin (HGB) |
EPIC Test Name
HEMOGLOBINEPIC Code
LAB291Specimen Requirements
Whole Blood | |
---|---|
Minimum Volume: | 2 mL |
Collection: | Collect using standard laboratory procedures |
Transport: | Room temperature, ASAP. |
Stability: | Room temperature: 24 hours. Refrigerated: 24-36 hours 2-8 degrees C. |
Container: | Lavender top (EDTA) |
Rejection Causes: | Clotted Insufficent Sample Volume |
Methods
SpectrophotometryTurnaround Time
Specimen | Turnaround Time | Frequency |
---|---|---|
Whole Blood | Stat : 90 minutes Routine: 4 hours | 24/7 |
Reference Ranges
Spectrophotometry
Age | Male Range | Female Range | Unit |
---|---|---|---|
0 days up to 14 days | 13.5-21.5 | 13.5-21.5 | g/dL |
14 days up to 29 days | 12.5-20.5 | 12.5-20.5 | |
29 day up to 2 months | 10 - 18 | 10-18 | |
2 months up to 3 months | 9 - 14 | 9-14 | |
3 months up to 6 months | 9.5-13.5 | 9.5-13.5 | |
6 months up to 2 years | 10.5-13.5 | 10.5-13.5 | |
2 years up to 6 years | 11.5-13.5 | ||
6 years up to 12 years | 11.5-15.5 | ||
12 years up to 18 years | 13-17 | ||
2 years up to 6 years | 11.5-13.5 | ||
6 years up to 999 years | 11.5-15.5 | ||
18 years up to 999 years | 13.5-18 |
Clinical Indications
Hemoglobin (Hb) consists of four subunits, 2 α-subunits and 2 non α-subunits (β-, γ-, or δ), whose primary function is to transport oxygen from the lungs to the body tissue, and CO2 from the prepheral tissues to the lungs. Each subunit has a binding site for heme with a Fe atom in the divalent state, whether Hb is oxygenated or deoxygenated.In healthy human adults, Hb A (α2β2) accounts about 96% of the total Hb in the whole blood, Hb A2 (α2δ2) is approximately 2.5% - 3.0% of total Hb; HbA2′, a variant of Hb A2, with a glycine-to-arginine substitution on the 16th position of the δ-chain, accounting 1%-2% of African Americans. Fetal Hb (Hb F) (α2γ2) is < 1% of total Hb.
Hb concentration measurement is used for diagnosis of anemia, often together with other hematological tests, e.g., erythrocyte count, or hematocrit.
Performed
Lab |
---|
Hematology - Community |
Hematology - Downtown |
Verona Cancer Center |
Interpretative Information
• For patients with hemoglobin levels below or lower than the reference interval, anemia can be diagnostic. The causes of anemia should be investigated and may include, though not limited to: deficiency of Iron, Vitamin B12 or/and Folate, bleeding, leukemia, kidney or/and liver disease, hypothyroidism, thalassemia.• For patients with hemoglobin levels higher than the reference range, its causes may include: polycythemia vera, lung disease (COPD associated with secondary polycythemia), dehydration, living at a high altitude, heavy smoking, burns, excessive vomiting, and extreme physical work-out.
CPT
85018LOINC
718-7References
1. Domenica Cappellini M, Lo SF, Swinkels DW. Hemoglobin, Iron, Bilirubin. In Tietz Textbook of Clinical Chemistry. Edited by N Rifai, AR Norwath and C Wittwer, 6 ed. St. Louis, Missouri, Elsevirer Inc, 2018, pp 719-42. ISBN: 978-0-323-35921-4Contact Information
Hematology - Downtown: (315)464-4460Hematology - Community: (315)492-5531
Verona Cancer Center: (315)473-3859