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Factor XII Activity (F12)

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EPIC Test Name

FACTOR 12 ASSAY

EPIC Code

LAB310

Specimen Requirements

Plasma
Minimum Volume:2.7 mL
Collection:Collect using standard laboratory procedures. Tubes must be full to obtain proper blood to anticoagulant ratio or the specimen will be rejected.
Transport:Specimens scheduled to arrive in lab in less than 4 hours can be sent at room temperature. Specimens arriving more than 4 hours must be platelet poor specimens and need to be frozen before transport. Place in an insulated container filled with dry ice to ensure that the specimen does not thaw.
Stability:Room temp: 4 hours Frozen: 2 weeks at -20 C 6 months at -70 C.
Container:Light-blue top (3.2% sodium citrate)
Processing/Storage:Specimens that cannot reach the lab within the time frame should be double spun at 2500 g for 15 minutes to obtain platelet poor plasma. 0.5mL aliquots should be frozen in plastic at -20 degrees C.
Rejection Causes:Clotted
Insufficent Sample Volume

Methods

Automated clotting assay

Turnaround Time

SpecimenTurnaround Time
PlasmaTesting is batched

Reference Ranges

Automated clotting assay
AgeAll RangeUnit
0 day13-93 U/dLU/dL
1 -5 days11-83 U/dL
5 days - 1 month17-81U/dL
1 - 3 months25-109 U/dL
3 - 6 months30-115 U/dL
>6 months69-197 U/dL

Clinical Indications

Diagnosis of Factor XII deficiency. Useful in the workup of unexpected prolongation of the PTT. Although Factor XII deficiency is not associated with bleeding, the PTT might be extremely prolonged.

Common Synonyms

Factor XII

Performed

Lab
Special Testing

CPT

85280

LOINC

3233-4

Contact Information

Special Testing: (315)464-4460
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