Cortisol 60min post (COR60) |
EPIC Test Name
CORTISOL 60 MINUTE POSTEPIC Code
LAB5901Specimen Requirements
plasma | |
---|---|
Minimum Volume: | 0.5 mL |
Collection: | Collect specimens using standard laboratory procedures. |
Transport: | Room Temperature ASAP |
Stability: | Room Temperature: 24 hours at 20-25 degrees C Refrigerated: 4 days at 2-8 degrees C Frozen: 12 months at -20 degrees C (freeze only once) |
Container: | LT GRN |
Rejection Causes: | Hemolysis, Insufficient Sample Volume |
Methods
ElectrochemiluminescenceTurnaround Time
Specimen | Turnaround Time | Frequency |
---|---|---|
plasma | Stat: 90 minutes Routine: 4 hours | 24/7 |
Reference Ranges
Electrochemiluminescence
All Range | Unit |
---|---|
After IV ACTH: >17.9 ug/dL | ug/dL |
After IM ACTH: >15.9 ug/dL |
Clinical Indications
ACTH given to normal subjects causes a rapid rise in the patient serum cortisol concentration. For patients with adrenal destruction (eg, Addison disease), cortisol concentration shall have no change or an inadequate change after ACTH stimulation. For patients with atrophy of the adrenal cortex caused by exogenous glucocorticoid treatment or dysfunction of the pituitary gland or hypothalamus, cortisol concentrations may show a slight rise, but not the magnitude as shown by the normal.Additional Information
A morning blood specimen is collected for determination of cortisol concentration as the baseline concentration; then 250 µg of cosyntropin is administered intramuscularly or intravenously. Specimens are subsequently collected at 30 and 60 minutes after injection and measured for cortisol concentrations.Common Synonyms
Cortisol 60min post CosyntropinPerformed
Lab |
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Chemistry - Community |
Chemistry - Downtown |
Interpretative Information
For a normal response, a peak cortisol concentration can be > 18 to 20 µg/dL (500–550 nmol/L) or greater and the expected change (delta) in cortisol concentration be 7 to 10 µg/dL (193–276 nmol/L). The peak cortisol value is more important than the incremental change. The incremental change may not be seen in patients who are tested at times of stress, since stress can increase or maximize the adrenal output of cortisol.CPT
82533LOINC
26528-0References
Berthold RL, cooper M, Winter WE. Adrnal Cortex. In Tietz Textbook of Clinical Chemistry. Edited by N Rifai, AR Norwath and C Wittwer, 6 ed. St. Louis, Missouri, Elsevirer Inc, 2018, pp 1530-71. ISBN: 978-0-323-35921-4Contact Information
Chemistry - Downtown: (315)464-4460Chemistry - Community: (315)492-5531