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Cortisol 60min post (COR60)

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EPIC Test Name

CORTISOL 60 MINUTE POST

EPIC Code

LAB5901

Specimen Requirements

plasma
Minimum Volume:0.5 mL
Collection:Collect specimens using standard laboratory procedures.
Transport:Room Temperature ASAP
Stability:Room Temperature: 24 hours at 20-25 degrees C
Refrigerated: 4 days at 2-8 degrees C
Frozen: 12 months at -20 degrees C (freeze only once)
Container:LT GRN
Rejection Causes:Hemolysis,
Insufficient Sample Volume

Methods

Electrochemiluminescence

Turnaround Time

SpecimenTurnaround TimeFrequency
plasmaStat: 90 minutes Routine: 4 hours24/7

Reference Ranges

Electrochemiluminescence
All RangeUnit
After IV ACTH: >17.9 ug/dLug/dL
After IM ACTH: >15.9 ug/dL

Clinical Indications

ACTH given to normal subjects causes a rapid rise in the patient serum cortisol concentration. For patients with adrenal destruction (eg, Addison disease), cortisol concentration shall have no change or an inadequate change after ACTH stimulation. For patients with atrophy of the adrenal cortex caused by exogenous glucocorticoid treatment or dysfunction of the pituitary gland or hypothalamus, cortisol concentrations may show a slight rise, but not the magnitude as shown by the normal.

Additional Information

A morning blood specimen is collected for determination of cortisol concentration as the baseline concentration; then 250 µg of cosyntropin is administered intramuscularly or intravenously. Specimens are subsequently collected at 30 and 60 minutes after injection and measured for cortisol concentrations.

Common Synonyms

Cortisol 60min post Cosyntropin

Performed

Lab
Chemistry - Community
Chemistry - Downtown

Interpretative Information

For a normal response, a peak cortisol concentration can be > 18 to 20 µg/dL (500–550 nmol/L) or greater and the expected change (delta) in cortisol concentration be 7 to 10 µg/dL (193–276 nmol/L). The peak cortisol value is more important than the incremental change. The incremental change may not be seen in patients who are tested at times of stress, since stress can increase or maximize the adrenal output of cortisol.

CPT

82533

LOINC

26528-0

References

Berthold RL, cooper M, Winter WE. Adrnal Cortex. In Tietz Textbook of Clinical Chemistry. Edited by N Rifai, AR Norwath and C Wittwer, 6 ed. St. Louis, Missouri, Elsevirer Inc, 2018, pp 1530-71. ISBN: 978-0-323-35921-4

Contact Information

Chemistry - Downtown: (315)464-4460
Chemistry - Community: (315)492-5531
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