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Chloride (CL)

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EPIC Test Name

CHLORIDE

EPIC Code

LAB59

Specimen Requirements

plasma
Minimum Volume:0.5 mL
Collection:Collect specimens using standard laboratory procedures.
Transport:Room Temperature ASAP
Stability:Refrigerated: 3 days at 2-8 degrees C (tightly capped)
Container:LT GRN
Rejection Causes:Hemolysis,
Insufficient Sample Volume

Methods

Direct Potentiometry

Turnaround Time

SpecimenTurnaround TimeFrequency
plasmaStat: 90 minutes Routine: 4 hours24/7

Reference Ranges

Direct Potentiometry
All RangeUnitCritical Values
98-107 mmol/Lmmol/L0-28 days old: <85 and >115 mmol/L

Clinical Indications

Chloride is the major extracellular anion, and plays important roles in maintaining homeostasis of water, osmotic pressure, and normal anion-cation balance.
Chloride is elevated many conditions including dehydration, renal tubular acidosis (hyperchloremia metabolic acidosis), acute renal failure, metabolic acidosis associated with prolonged diarrhea and loss of sodium bicarbonate, diabetes insipidus, adrenocortical hyperfunction, salicylate intoxication, and with excessive infusion of isotonic saline or extremely high dietary intake of salt. Hyperchloremia acidosis may be a sign of severe renal tubular malfunction.

Conditions associated with decreased Chloride concentration include overhydration, chronic respiratory acidosis, salt-losing nephritis, metabolic alkalosis, congestive heart failure, Addisonian crisis, certain types of metabolic acidosis, persistent gastric secretion and prolonged vomiting, aldosteronism, bromide intoxication, syndrome of inappropriate antidiuretic hormone secretion, and conditions associated with expansion of extracellular fluid volume.

Additional Information

Falsely high chloride values have been reported from patients receiving perchlorate medication. This is due to an interference of perchlorate ions with chloride ISE determination.

Common Synonyms

CL

Performed

Lab
Chemistry - Community
Chemistry - Downtown
Verona Cancer Center

Interpretative Information

In healthy subjects, serum chloride values remain constant or vary slightly throughout the day, though a slight decrease may occur postprandially as a result of chloride usage in the production of gastric juice.

CPT

82435

LOINC

2075-0

References

Tietz Textbook of clinical chemistry and molecular Diagnostics. Eds. Burtis C, Ashwood ER, Bruns D. 5th ED. 2012 Page: 509-63.

Contact Information

Chemistry - Downtown: (315)464-4460
Chemistry - Community: (315)492-5531
Verona Cancer Center: (315)473-3859
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