Chloride (CL) |
EPIC Test Name
CHLORIDEEPIC Code
LAB59Specimen Requirements
plasma | |
---|---|
Minimum Volume: | 0.5 mL |
Collection: | Collect specimens using standard laboratory procedures. |
Transport: | Room Temperature ASAP |
Stability: | Refrigerated: 3 days at 2-8 degrees C (tightly capped) |
Container: | LT GRN |
Rejection Causes: | Hemolysis, Insufficient Sample Volume |
Methods
Direct PotentiometryTurnaround Time
Specimen | Turnaround Time | Frequency |
---|---|---|
plasma | Stat: 90 minutes Routine: 4 hours | 24/7 |
Reference Ranges
Direct Potentiometry
All Range | Unit | Critical Values |
---|---|---|
98-107 mmol/L | mmol/L | 0-28 days old: <85 and >115 mmol/L |
Clinical Indications
Chloride is the major extracellular anion, and plays important roles in maintaining homeostasis of water, osmotic pressure, and normal anion-cation balance.Chloride is elevated many conditions including dehydration, renal tubular acidosis (hyperchloremia metabolic acidosis), acute renal failure, metabolic acidosis associated with prolonged diarrhea and loss of sodium bicarbonate, diabetes insipidus, adrenocortical hyperfunction, salicylate intoxication, and with excessive infusion of isotonic saline or extremely high dietary intake of salt. Hyperchloremia acidosis may be a sign of severe renal tubular malfunction.
Conditions associated with decreased Chloride concentration include overhydration, chronic respiratory acidosis, salt-losing nephritis, metabolic alkalosis, congestive heart failure, Addisonian crisis, certain types of metabolic acidosis, persistent gastric secretion and prolonged vomiting, aldosteronism, bromide intoxication, syndrome of inappropriate antidiuretic hormone secretion, and conditions associated with expansion of extracellular fluid volume.
Additional Information
Falsely high chloride values have been reported from patients receiving perchlorate medication. This is due to an interference of perchlorate ions with chloride ISE determination.Common Synonyms
CLPerformed
Lab |
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Chemistry - Community |
Chemistry - Downtown |
Verona Cancer Center |
Interpretative Information
In healthy subjects, serum chloride values remain constant or vary slightly throughout the day, though a slight decrease may occur postprandially as a result of chloride usage in the production of gastric juice.CPT
82435LOINC
2075-0References
Tietz Textbook of clinical chemistry and molecular Diagnostics. Eds. Burtis C, Ashwood ER, Bruns D. 5th ED. 2012 Page: 509-63.Contact Information
Chemistry - Downtown: (315)464-4460Chemistry - Community: (315)492-5531
Verona Cancer Center: (315)473-3859