CKMB (CKMB1) |
EPIC Test Name
CKMBEPIC Code
LAB2577Specimen Requirements
plasma | |
---|---|
Minimum Volume: | 0.5 mL |
Collection: | Collect using standard laboratory procedures |
Transport: | Room Temperature ASAP |
Stability: | Refrigerated: 5 days at 2-8 degrees C Frozen: 3 months at -20 degrees C |
Container: | LIT-GRN |
Processing/Storage: | Centrifuge pour off and freeze. |
Rejection Causes: | Hemolysis, Insufficient Sample Volume, lipemic samples |
Methods
ElectrochemiluminescenceTurnaround Time
Specimen | Turnaround Time | Frequency |
---|---|---|
plasma | 5 days | Run Tuesdays and Fridays |
Reference Ranges
Electrochemiluminescence
Male Range | Female Range | Unit |
---|---|---|
<10.4 ng/mL | <5.4 ng/mL | ng/mL |
Clinical Indications
• Creatine kinase (CK) is a dimeric enzyme. CK-MB is a type of isoenzyme of Creatine kinase (CK), the other types are: a mitochondrial isoenzyme and the cytosolic isoenzymes CK-MM (muscle type) and CK-BB (brain type).• If ordering CK-MB test is for diagnosis of myocardial ischemia, the order should be replaced with high sensitive cardiac troponin T (hs-cTnT), which is offered at the Core/Chemistry laboratory, due to that elevated CKMB is not specific to myocardial infarction with, in addition, low clinical sensitivity.
Common Synonyms
MB-isoenzymePerformed
Lab |
---|
Chemistry - Community |
Interpretative Information
• Elevated CKMB is not specifically associated with MI (myocardial infarction). It may also be caused by other disease states. Elevated CK-MB values should always be interpreted in conjunction with patient clinical presentation and medical history.• CK-MB clinical sensitivity is dependent upon the time of sampling is association with the time of MI occurrence. Follow-up assays are recommended for clinical meaningful results.
• CK-MB determination by immunoassay assays may have clinical values in estimating the extent of myocardial necrosis, therefore, MI patient prognosis. For such purpose, frequent sampling to ensure that peak CK-MB values are correctly identified is needed.
• Though the CKMM mainly exists in the skeletal muscle, some skeletal muscle diseases or chronical damage (e.g., extreme exercise) may contain significant proportions of CK-MB owing to the phenomenon of “fetal reversion,” in which fetal patterns of protein synthesis (in the case of CK, the B monomer) reappear. Thus, serum CKMB may increase in such circumstances. This may explain the elevated CKMB values sometimes occur in chronic renal failure (uremic myopathy).
CPT
82553LOINC
13969-1References
1. Bagai A, Schulte PJ, Granger CB, et al.: Prognostic implications of creatine kinase-MB measurements in ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention. Am Heart J. 168:503-511 2014. PMID 252622602. Panteghini M and Bais R. Serum Enzymes. In Tietz Textbook of Clinical Chemistry. Edited by N Rifai, AR Norwath and C Wittwer, 6 ed. St. Louis, Missouri, Elsevirer Inc, 2018, pp 408-11. ISBN: 978-0-323-35921-4