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CKMB (CKMB1)

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EPIC Test Name

CKMB

EPIC Code

LAB2577

Specimen Requirements

plasma
Minimum Volume:0.5 mL
Collection:Collect using standard laboratory procedures
Transport:Room Temperature ASAP
Stability:Refrigerated: 5 days at 2-8 degrees C
Frozen: 3 months at -20 degrees C
Container:LIT-GRN
Processing/Storage:Centrifuge pour off and freeze.
Rejection Causes:Hemolysis,
Insufficient Sample Volume, lipemic samples

Methods

Electrochemiluminescence

Turnaround Time

SpecimenTurnaround TimeFrequency
plasma5 daysRun Tuesdays and Fridays

Reference Ranges

Electrochemiluminescence
Male RangeFemale RangeUnit
<10.4 ng/mL<5.4 ng/mLng/mL

Clinical Indications

• Creatine kinase (CK) is a dimeric enzyme. CK-MB is a type of isoenzyme of Creatine kinase (CK), the other types are: a mitochondrial isoenzyme and the cytosolic isoenzymes CK-MM (muscle type) and CK-BB (brain type).
• If ordering CK-MB test is for diagnosis of myocardial ischemia, the order should be replaced with high sensitive cardiac troponin T (hs-cTnT), which is offered at the Core/Chemistry laboratory, due to that elevated CKMB is not specific to myocardial infarction with, in addition, low clinical sensitivity.

Common Synonyms

MB-isoenzyme

Performed

Lab
Chemistry - Community

Interpretative Information

• Elevated CKMB is not specifically associated with MI (myocardial infarction). It may also be caused by other disease states. Elevated CK-MB values should always be interpreted in conjunction with patient clinical presentation and medical history.
• CK-MB clinical sensitivity is dependent upon the time of sampling is association with the time of MI occurrence. Follow-up assays are recommended for clinical meaningful results.
• CK-MB determination by immunoassay assays may have clinical values in estimating the extent of myocardial necrosis, therefore, MI patient prognosis. For such purpose, frequent sampling to ensure that peak CK-MB values are correctly identified is needed.
• Though the CKMM mainly exists in the skeletal muscle, some skeletal muscle diseases or chronical damage (e.g., extreme exercise) may contain significant proportions of CK-MB owing to the phenomenon of “fetal reversion,” in which fetal patterns of protein synthesis (in the case of CK, the B monomer) reappear. Thus, serum CKMB may increase in such circumstances. This may explain the elevated CKMB values sometimes occur in chronic renal failure (uremic myopathy).

CPT

82553

LOINC

13969-1

References

1. Bagai A, Schulte PJ, Granger CB, et al.: Prognostic implications of creatine kinase-MB measurements in ST-segment elevation myocardial infarction patients treated with primary percutaneous coronary intervention. Am Heart J. 168:503-511 2014. PMID 25262260
2. Panteghini M and Bais R. Serum Enzymes. In Tietz Textbook of Clinical Chemistry. Edited by N Rifai, AR Norwath and C Wittwer, 6 ed. St. Louis, Missouri, Elsevirer Inc, 2018, pp 408-11. ISBN: 978-0-323-35921-4

Contact Information

Chemistry - Community: (315)492-5531
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