Physicians & Faculty

Shengle Zhang, MD

Shengle Zhang, MD
Appointed 07/01/04
6804C Upstate University Hospital - Downtown Campus
750 East Adams Street
Syracuse, NY 13210

315 464-4750

Current Appointments

Hospital Campus

  • Downtown
  • Community

Clinical Section Affiliations

  • Pathology: Anatomic Pathology, Lymphocyte Lab, Molecular Diagnostics, Surgical Pathology
  • Pathology - Community Campus

Research Programs and Affiliations

  • Cancer Research Program
  • Pathology

Education & Fellowships

  • Fellowship: Johns Hopkins Medical Institutions, Maryland., 2004, Molecular Genetic Pathology/Molecular Diagnostics
  • Fellowship: Roswell Park Cancer Center, New York, 2002, Oncologic Pathology
  • Residency: Saint Barnabas Health Care System, New Jersey, 2001, Anatomic and Clinical Pathology
  • MS: Shangdong Academy of Medical Sciences, 1985, Biochemistry
  • MD: Wannan Medical College, China, 1982, Medicine

Clinical Interests

  • Surgical pathology, molecular pathology

Research Interests

  • Molecular Oncology and its clinical application.

Specialties & Certification

  • Anatomic and Clinical Pathology
  • Molecular Diagnostics (ABCC)
  • Molecular Genetic Pathology


  • Adults and Children


  • Genetic Testing
  • Laboratory Services


  • American Society for Clinical Pathology
  • Association of Molecular Pathology (AMP)
  • United States and Canadian Academy of Pathology
  • American Association for Cancer Research (AACR)

Current Hospital Privileges

  • Upstate University Hospital

Web Resources


Link to PubMed External Icon (Opens new window. Close the PubMed window to return to this page.)


Recent Selected References:

  1. Shengle Zhang, Bin Yang. Development and Validation of Molecular Testing on Cytologic Specimens (Chapter 1). In: Molecular Cytopathology, Essentials in Cytopathology 26. Ed(s). B. Yang, J Rao, Springer, Switzerland. 2016, 1-15.
  2. Shengle Zhang, Dongfeng Tan. Introduction of Molecular Techniques and Instrumentation (Chapter 7). In: Principles of Molecular Diagnostics and Personalized Cancer Medicine. Ed(s) Tan D, Lynch H, Lippincott Williams & Wilkins. 2013, 70-85.
  3. Shengle Zhang, Transcriptome Analysis. In: Principles of Molecular Diagnostics and Personalized Cancer Medicine (Chapter 8). Ed(s) Tan D, Lynch H, Lippincott Williams & Wilkins. 2013, 86-95.
  4. Shengle Zhang. Molecular Pathology of Gastric Neoplasms (Chapter 13). In: Dongfeng Tan and Gregory Lauwers, eds. Advances in Surgical Pathology - Gastric Cancer. Wolters Kluwer/Lippincott Williams & Wilkins, Philadelphia; 2011, 189-200.


Selected Articles

  1. Deng X, Wei JJ, Zhang S. Screening genetic alterations of biomarkers BRAF, ROS-1, and HER2 by immunohistochemistry in ovarian carcinomas for targeted therapy. N A J Med Sci. 2017;10(2):53-55.
  2. Naous R*, Zhang S, Valente A, Stemmer M, and Khurana KK. Utility of immunohistochemistry and ETV6 (12p13) gene rearrangement in identifying secretory carcinoma of salivary gland among previously diagnosed cases of acinic cell carcinoma. Pathol Res Int 2017:1-7, 2017.
  3. Zaccarini DJ, Deng XB Tull J, Maciak C,Valente AL, Zhang S. Expression of TLE-1 and CD99 in Carcinoma: Pitfalls in Diagnosis of Synovial Sarcoma. Appl Immunohistochem Mol Morphol. 2016(October), Published Ahead-of-Print.
  4. Xu W*, Khurana K, Tull J, Maciak C, Zhang S. Destaining of Diff-Quik stained cytologic smears is not necessary for FISH analysis of ALK gene rearrangement in lung adenocarcinoma. J Amer Soc Cyotopathol 4(6):S48-49, 2015.
  5. Valente AL, Whiting K*, Tull J, Maciak C, Zhang S. Immunohistochemical study of BRAF V600E mutant protein expression in high-grade sarcomas. Journal of Solid Tumors. 5:44-48, 2015.
  6. Alfredo L. Valente, AL, Tull J, Zhang S. Specificity of TLE1 expression in unclassified high-grade sarcomas for the diagnosis of synovial Sarcoma. Appl Immunohistochem Mol Morphol 21:408–413, 2013.
  7. Rong R, Tull J, Zhang S. Molecular Biomarker Profile of EGFR Copy Number, KRAS and BRAF Mutations in Colorectal Carcinoma. J Solid Tumors. 2(4):27-31, 2012.
  8. Valente, AL, Tull, J, Zhang, S. Utility of fluorescence in situ hybridization in sub-classifying unclassified high-grade sarcomas: a study of 40 cases using break-apart probes of EWSR1, FOXO1A, SS18 and DDIT3 Genes. J Solid Tumors. 2(2):4-9, 2012.
  9. Swati I, Zhang S, Tull J, Khurana KK. Accuracy of cytology specimen and needle core biopsies for detection of KRAS mutation in non-small cell carcinoma: comparison with resection specimen. World J Oncol. 2(6):275-280, 2011.
  10. Narendra S, Valente A, Tull J, Zhang, S. DDIT3 gene break-apart as a molecular marker for diagnosis of myxoid liposarcoma - assay validation and clinical experience. Diagn Mol Pathol, 20:218-224, 2011.
  11. Deng FM, Galvan K, de la Roza G, Zhang S, Souid AK, Stein CK.Molecular characterization of an EWSR1-POU5F1 fusion associated with a t(6;22) in an undifferentiated soft tissue sarcoma. Cancer Genet. 204:423-429, 2011.
  12. Zhang S, Pavlovitz B, Tull J, Wang Y, Deng F, Fuller C. Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia and normal epithelium of the prostate by direct fluorescence in situ hybridization. Diagn Mol Pathol, 19:151-156, 2010.
  13. Nasr MR, Mukhopadhyay S, Zhang S, and Katzenstein ALA. Absence of BRAF mutation in HBME1 And CK19 positive atypical cell clusters in hashimoto’s thyroiditis: evidence against preneoplastic change.  Am J Clin Pathol, 132:906-912, 2009.
  14. El-Zammar O, Zhang S, Katzenstein ALA. Comparison of FISH, PCR, and Immunohistochemistry in assessing EGFR status in lung adenocarcinoma and correlation with clinicopathologic features. Diagn Mol Pathol, 18:133-137, 2009.
  15. Shah SS, Wang Y, Tull J and Zhang S. Effect of high copy number of HER2 associated with polysomy 17 on HER2 protein expression in invasive breast carcinoma. Diagn Mol Pathol, 18:30-33, 2009.
  16. Mehra S, de la Roza G, Tull J, Shrimpton A, Valente A, Zhang S. Detection of FOXO1(FKHR) gene break-apart by fluorescence in situ hybridization (FISH) in formalin fixed paraffin embedded alveolar rhabdomyosarcomas and its clinicopathological correlation. Diagn Mol Pathol, 17:14-20, 2008.
  17. Nasr, MR, Mukhopadhyay S, Zhang S and Katzenstein A-L: Immunohistochemical markers in diagnosis of papillary thyroid carcinoma: utility of HBME1 combined with CK19 immunostaining. Mod Pathol, 19:1631-1637, 2006.
  18. Murphy K, Zhang S, Geiger T, Hafez MJ, Bacher J, Berg KD and Eshleman J. Comparison of the microsatellite instability analysis system and the Bethesda panel for the determination of microsatellite instability in colorectal cancers. J Mol Diagn 8:305-11, 2006.

Clinical Profile Shortcut:
Faculty Profile Shortcut:

Adjunct Faculty

Emeritus Faculty

  • Frederick Davey, MD
  • Gerald Gordon, MD
  • Lawrence Gordon, MD
  • Anna-Luise Katzenstein, MD
  • Bedros Markarian, MD
  • Michael Mazur, MD
  • Albert Oler, MD
  • Robert Rohner, MD
  • Constance Stein, PhD
  • Gregory Threatte, MD