The Yang LabEmotional feeding circuit
The Zhu LabStudying Neural Stem Cells
The Yang LabStudying functional role of glia
Jeremy M Shefner, MD, PhD
Clinical Section Affiliations
Research Programs and Affiliations
- Neuroscience Program
Education & Fellowships
- Fellowship: Harvard Medical School, 1990, Clinical Neurophysiology
- Residency: Harvard Medical School, 1988
- Residency: Beth Israel Hospital, 1984
- MD: Northwestern University Medical School, 1983
- PhD: University of Illinois at Chicago, 1976
- Brigham and Women's Hospital, 1990–1996
- I direct the MDA/ALS Research and Treatment Center and the ALS Association sponsored ALS Clinic at University Hospital where patients with ALS are treated by a multidisciplinary clinical team. I am also interested in the electrodiagnosis and treatment of patients with a variety of neuromuscular disorders.
Clinical Therapeutics of ALS and other motor neuron disorders. Animals models of the physiology and treatment of amyotrophic lateral sclerosis (ALS); Peripheral nerve physiology.
Specialties & Certification
- Clinical Neurophysiology
Diseases & Conditions Treated
- Lou Gehrig's Disease
- Botulinum Toxin Injections
- ALS Association (ALSA)
- American Neurological Association
- American Academy of Neurology (AAN)
Current Hospital Privileges
- Upstate University Hospital
Link to PubMed (Opens new window. Close the PubMed window to return to this page.)
Therapeutic Trials in Patients with ALS.
With Dr. Merit Cudkowicz of Massachusetts General Hospital, I am co Chair of the Northeast ALS Clinical Trials Consortium (NEALS). NEALS is the largest ALS research consortium in the world, consisting of 97 clinical trial sites in the US and Canada. We have performed 8 clinical trials in the last 10 years, and are currently involved in 5 ongoing trials. I am co-principal investigator of the NIH funded trial of Ceftriaxone in ALS, and am the lead investigator in the ongoing development of a fast skeletal muscle activator in collaboration with Cytokinetics, Inc. NEALS has established a significant clinical trials infrastructure, including cores for clinical trial management, an electronic data capture system, data management, outcomes measure training, and clinical monitoring cores. These are distributed between Upstate Medical University and Massachusetts General Hospital in Boston, MA.
Studies of motor units in patients with ALS and other motor neuron diseases
I have developed a new method for the non-invasive assessment of motor units in patients with ALS and other motor neuron disorders. The first analysis of patients with ALS using this method has recently been published in Neurology. This method is now being employed in multicenter trials of patients with ALS and Spinal Muscular Atrophy. I am responsible for training and validation of sites, and expect that these studies will both provide valuable insight into the pattern of motor neuron loss in these diseases, as well as provide a sensitive marker of therapeutic efficacy.
Faculty Profile Shortcut: http://www.upstate.edu/faculty/shefnerj