Faculty Research Interests

Steven M Taffet, PhD

Steven M Taffet, PhD
Appointed 05/08/85
2235A Weiskotten Hall
766 Irving Ave.
Syracuse, NY 13210

315 464-5419

Current Appointments

Hospital Campus

  • Downtown

Research Programs and Affiliations

  • Biomedical Sciences Program
  • Microbiology and Immunology

Education & Fellowships

  • PhD: University of North Carolina at Chapel Hill, 1981

Research Interests

  • Investigate the role of Cx43 gap junctions and hemichannels in immunity

Publications

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Research Abstract

Role of Connexin43 (Cx43) in the immune System

We have developed a model system to study the role of the gap junction protein Cx43 in the immune system of mice. There are many reports that suggest that Cx43 is a critical for a variety of immune functions. We are particularly interested in the role of connexins in the function of macrophages and dendritic cells during antigen presentation and induction of tolerance.

Role of Gap Junctions and Tunneling Nanotubes in Cystinosis.

There is evidence that transplanted macrophages may act to correct the lysosomal transport disease, Cystinosis. We have been exploring the role of Cx43 in the formation and function of the tunneling nanotube.

Selected References

Glass, A.M., Snyder, E.G., Taffet, S.M.. Connexins and pannexins in the immune system and lymphatic organs.Cell Mol Life Sci. 72:2899-910 (2015)

Morel, S., Chanson, M., Nguyen, T.D., Glass, A.M., Richani Sarieddine, M.Z., Meens, M.J., Burnier, L, Kwak BR, Taffet SM., Titration of the gap junction protein Connexin43 reduces atherogenesis. Thrombosis and Haemostasis 112:390-401, (2014)

Glass, A.M., Coombs, W., Taffet, S.M. Spontaneous cardiac calcinosis in BALB/cByJ mice. Comparative Med. 63:29-37. (2013)

Glass, A.M., Wolf, B.J., Schneider K.M., Princiotta, M.F., Taffet, S.M. Connexin43 is dispensable for phagocytosis J Immunol;190:4830-5 (2013).

 

Faculty Profile Shortcut: http://www.upstate.edu/faculty/taffets
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