Research Faculty

Kan Liu, MD, PhD

Kan Liu, MD, PhD
Appointed 09/21/09
Women's Health Network
5TH FL University Health Care Center
90 Presidential Plaza
Syracuse, NY 13202

315 464-4536

Current Appointments

Hospital Campus

  • Downtown
  • Community

Clinical Section Affiliations

  • Medicine: Cardiology
  • Medicine - Community Campus: Cardiology
  • Upstate Heart and Vascular Center: Cardiology

Research Programs and Affiliations

  • Medicine

Clinic/Unit

Education & Fellowships

  • Fellowship: Washington University at St. Louis, 2009, Cardiology
  • Residency: University of Texas Medical Branch Hospitals, 2006, Internal Medicine
  • Additional Training: University of Alabama at Birmingham, 2003, Research Assistant Professor
  • Additional Training: University of Alabama at Birmingham, 2002, Instructor, Internal Medicine
  • PhD: University of Alabama at Birmingham, 2001, Internal Medicine and Cellular Biology
  • MD: Sun Yat-Sen University of Medical Sciences, 1992

Clinical Interests

  • -Cardiology consult
    -Invasive cardiology and cardiovascular imaging,
    -Coronary artery disease prevention.

Research Interests

  • -Endothelial dysfunction in coronary artery disease.
    -Lipotoxicity/glucotoxicity and endothelial/myocyte dysfunction in diabetes.
    -Clinical and genetic analysis of valve diseases/Strain/strain rate imagine in cardiomyopathy.

Specialties & Certification

  • Internal Medicine
  • Cardiology
  • Cardiovascular Computed Tomography
  • Echocardiography
  • Nuclear Cardiology
  • Cardiovascular MRI

Diseases & Conditions Treated

  • Abdominal Aortic Aneurysm (AAA)
  • Angina
  • Aortic Aneurysm
  • Aortic Valve Regurgitation
  • Arrhythmias
  • Ascending Aortic Aneurysm
  • Atherosclerosis
  • Atrial Fibrillation
  • Atrial Septal Defect (ASD)
  • Blood Clots
  • Cardiac Arrest
  • Cardiomyopathy
  • Carotid Artery Aneurysm
  • Heart Disease
  • Heart Disease and Women
  • Heart Failure
  • Heart Infection
  • Heart Murmur
  • Heart Palpitations
  • Heart Valve Disease
  • Heat Illness
  • Murmers
  • Myocarditis
  • Syncope

Treats

  • Adults

Treatments/Services

  • Angiogenesis
  • Angiography
  • Aortic Dissection Treatment
  • C-Reactive Protein Testing
  • Calcium-Score Screening Heart Scan
  • Cardiac Catheterization
  • Cardiac Computed Tomography
  • Cardiovascular MRI
  • Cardioversion
  • Chest Pain Treatment
  • Chest X-Ray - Heart
  • Echocardiography
  • Exercise Stress Echocardiogram
  • Exercise Stress Test
  • Heart Nuclear Imaging
  • Heart Nuclear Stress Testing
  • Heart Ultrasounds
  • Non-Invasive Testing for Vascular Disease
  • Nuclear Adenosine Stress Test
  • Nuclear Exercise Stress Test
  • Nuclear Imaging
  • Women's Health

Associations/Memberships

  • American Heart Association (AHA)
  • Society of Cardiovascular CT (SCCT)
  • American College of Physicians (ACP)
  • American Society of Echocardiography (ASE)
  • Society of Cardiovascular MRI (SCMR)
  • American College of Cardiology (ACC)

Current Hospital Privileges

  • Upstate University Hospital
  • Crouse Hospital
  • VA Medical Center

Languages Spoken (Other Than English)

  • Chinese

Publications

Link to PubMed External Icon (Opens new window. Close the PubMed window to return to this page.)

Research Abstract

Recent publications:

 Book chapter:

Liu K: The Washington Manual, Cardiology Subspecialty Consult. Wolter Kluwer | Lippincott Williams & Wilkins. Chapter 29 (2008):. Diabetes and Cardiovascular Diseases

 Original Papers:

Roh M, Paterson AJ, Liu K, McAndrew J, et al. Proteolytic processing of TGFα redirects its mitogenic activity: the membrane-anchored form is autocrine, the secreted form is paracrine. Biochim Biophys Acta-Mol Cell Res 2005, 1743 (3):231-242.

Liu K, Paterson AJ, Zhang F, et al. Accumulation of protein O-GlcNAc modification inhibits proteasomes in the brain and coincides with neuronal apoptosis in brain areas with high O-GlcNAc metabolism. J Neurochem. 2004, 89 (4): 1044-1055.

Liu K, Paterson AJ, Konrad RJ, et al. Streptozotocin, an O-GlcNAcase inhibitor, blunts insulin and growth hormone Secretion. Mol Cell Endocrinol. 2002, 194(1-2): 135-146.

Liu K, Paterson AJ, Chin E et al. Glucose stimulates protein modification by O-linked GlcNAc in pancreatic beta cells: linkage of O-linked GlcNAc to beta cell death.  Proc Natl Acad Sci U S A. 2000, 97(6): 2820-2825.

Liu K, Ou J, Saku K, et al. Efficient nuclear delivery of antisense oligodeoxynucleotides and selective  inhibition of CETP expression by apo E peptide in a human CETP-stably transfected CHO cell line. Arterioscler Thromb Vasc Biol. 1999,19:2207-2213.

Konrad RJ, Mikolaenko I, Tolar JF, Liu K, et al.. The potential mechanism of the  diabetogenic action of streptozotocin: inhibition of pancreatic beta-cell O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase. Biochem. J. 2001, 356(Pt 1):31-41.

Konrad RJ, Liu K, Kudlow JE. A modified method of islet isolation preserves the ability of  pancreatic islets to increase protein O-glycosylation in response to glucose and streptozotocin. Arch. Biochem. Biophys. 2000 Sep 1; 381(1):92-98

Clinical Profile Shortcut: http://www.upstate.edu/findadoc/liuk
Faculty Profile Shortcut: http://www.upstate.edu/faculty/liuk