MD/PHD PROFILE
Hans Kim

Hans Kim

"I have numerous opportunities to get involved in activities and trainings to improve our skills needed for publications." Read More...

Current Students

Darin Dolezal

Darin Dolezal

PhD (5th year)
dolezald@upstate.edu

Department: Biochemistry & Molecular Biology
Advisor: Francesca Pignoni, PhD

Research Interests

I'm interested in understanding the processes that are needed to regulate stem cells throughout life. Adult stem cells, such as hematopoietic stem cells or germline stem cells, have the remarkable ability to continually self-renew and replenish differentiated cells that need to be replaced. Normal tissue homeostasis requires precise control over stem cell division and differentiation, and unregulated stem cell growth is a pathologic feature of cancers and disease. Regulation of stem cells is achieved by both extrinsic signals and intrinsic factors that instruct the cell either to self-renew/divide or to differentiate into mature cells. Investigations into stem cell regulation have demonstrated that stem cells reside within sophisticated microenvironments, called niches, where neighboring cells provide the signaling milieu needed for regulating self-renewal and differentiation. The molecular mechanisms needed to maintain stem cells within these niches, however, are still unclear. I'm applying biochemical, genetic and cell biology approaches to understand the molecular components involved stem cell maintenance and niche function.