Major Research Areas
Yunlei Yang, MD, PhD
- Associate Professor of Neuroscience and Physiology
Research Programs and Affiliations
- Biomedical Sciences Program
- Neuroscience Program
- Neuroscience and Physiology
Deciphering and manipulating cellular, synaptic, and circuit mechanisms governing feeding and anxiety-related behavior with genetic and system neuroscience approaches
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The focus of Dr. Yang's research is on dissecting and manipulating intracellular and intercellular signaling circuits governing feeding and anxiety-related behaviors in normal and obese animals using genetic and systems neuroscience approaches that include cell-type-specific electrophysiology, optogenetics, chemical-genetics, deep-brain measurements of neurochemicals, imaging, and behavior assays. One of the projects in Dr. Yang's laboratory is about synaptic and circuit rewiring in obesity. Obesity and its associated pathologies impose a huge burden to our society. Obesity may increase the risks of many other complications, such as type 2 diabetes and psychological disorders including anxiety. However, the mechanisms and the effective treatments of obesity and the associated disorders are largely unknown. It thus is critical to determine the cellular, synaptic, and circuit mechanism(s) underlying feeding and anxiety, providing apparent therapeutic target(s) for the treatment of obesity, eating disorders, and anxiety.
In addition to neuronal regulations of energy states and anxiety, Dr. Yang is also interested in studying the roles played by astrocytes in these regulations in both normal and abnormal conditions, including obesity and anxiety disorders.
Sweeney P1, O'Hara K1, Xu Z, Yang Y*. HFD-induced energy states-dependent bidirectional control of anxiety levels in mice. Int J Obes (Nature press; London). 2017. In print. 1. co-first authors.
Sweeney P, Yang Y*. Neural circuit mechanisms underlying emotional regulation of homeostatic feeding. Trends Endocrinol Metab. 2017 June; 6(28):437-448. PMID:28279562.
Sweeney P, Yang Y*. An Inhibitory Septum to Lateral Hypothalamus Circuit That Suppresses Feeding. J Neurosci. 2016 Nov 2;36(44):11185-11195. PMID:27807162 Featured Article
Sweeney P, Qi Y, Xu Z, Yang Y*. Activation of hypothalamic astrocytes suppresses feeding without altering emotional states. Glia. 2016 Dec. 64(12):2263-2273. doi: 10.1002/glia.23073. PMID:27658520
Sweeney P, Levack R, Watters J, Xu Z, Yang Y*. Caffeine increases food intake while reducing anxiety-related behaviors. Appetite. 2016 Jun 1;101:171-7. doi: 10.1016/j.appet.2016.03.013. Epub 2016 Mar 10.PMID:26972351
Sweeney P, Yang Y*. An excitatory ventral hippocampus to lateral septum circuit that suppresses feeding. Nat Commun. 2015 Dec 15;6:10188. doi: 10.1038/ncomms10188.PMID:26666960 Featured by Faculty 1000Prime: http://f1000.com/prime/article?articleId=726014683&emailType=ts
Qi Y, Yang Y*. Hunger States Control the Directions of Synaptic Plasticity via Switching Cell Type-Specific Subunits of NMDA Receptors. J Neurosci. 2015 Sep 23;35(38):13171-82. doi: 10.1523/JNEUROSCI.0855-15.2015.PMID:26400946
Yang L, Qi Y, Yang Y*. Astrocytes control food intake by inhibiting AGRP neuron activity via adenosine A1 receptors. Cell Rep. 2015 May 5;11(5):798-807. doi: 10.1016/j.celrep.2015.04.002. Epub 2015 Apr 23.PMID:25921535 Comment in: Regulation of orexigenic AgRP neurons: A third way? [Trends Endocrinol Metab. 2015] Commentary in Cell Press: http://news.cell.com/cellreports/cell-reports/eating-and-the-brain-glial-cells-enter-the-fray-a-guest-commentary Featured in World Biomedical Frontiers: http://biomedfrontiers.org/diabetes-obesity-2015-9-2/
Yang Y, Lee P, Sternson SM. Cell type-specific pharmacology of NMDA receptors using masked MK801. Elife. 2015 Sep 11;4. doi: 10.7554/eLife.10206.PMID:26359633.
Tian L, Yang Y, Wysocki LM, Arnold AC, Hu A, Ravichandran B, Sternson SM, Looger LL, Lavis LD. Selective esterase-ester pair for targeting small molecules with cellular specificity. Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4756-61. doi: 10.1073/pnas.1111943109. Epub 2012 Mar 12.PMID:22411832 Featured in Faculty of 1000 Biology
Yang Y, Atasoy D, Su HH, Sternson SM. Hunger states switch a flip-flop memory circuit via a synaptic AMPK-dependent positive feedback loop. Cell. 2011 Sep 16;146(6):992-1003. doi: 10.1016/j.cell.2011.07.039.PMID:21925320 Previewed in Cell, and Cell Metabolism; Highlighted in "Editor Choice" in Science Signaling and Featured in Faculty of 1000 Biology
Yang Y*, Wang XB, Zhou Q*. Perisynaptic GluR2-lacking AMPA receptors control the reversibility of synaptic and spines modifications. Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11999-2004. doi: 10.1073/pnas.0913004107. Epub 2010 Jun 14.PMID:20547835
Yang Y, Zhou Q. Spine modifications associated with long-term potentiation. Neuroscientist. 2009 Oct;15(5):464-76. doi: 10.1177/1073858409340800. Review.PMID:19826170 (invited review)
Yang Y, Wang XB, Frerking M, Zhou Q. Delivery of AMPA receptors to perisynaptic sites precedes the full expression of long-term potentiation. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11388-93. doi: 10.1073/pnas.0802978105. Epub 2008 Aug 5.PMID:18682558Featured by Faculty of 1000 Biology