Rosemary Rochford, PhD

Rosemary Rochford, PhD
Appointed 09/02/03
2120 Weiskotten Hall
766 Irving Ave.
Syracuse, NY 13210

315 464-5453

Current Appointments

Hospital Campus

  • Downtown

Research Programs and Affiliations

  • Biomedical Sciences Program
  • Cancer Research Institute
  • Microbiology and Immunology
  • Research Pillars

Education & Fellowships

  • PhD: University of California at Irvine, 1989

Research Interests

  • Etiology of viral-associated malignancies, gammaherpesvirus pathogenesis.

HealthLinkOnAir Radio Interview

11/21/13 Unveiling Upstates new Neuroscience Research Building

5/15/13 How will the NIH grant funding sequester affect local research?

3/13/13 Challenges in Cancer Research in Africa

4/29/12 Bird flu virus controversy


Link to PubMed External Icon (Opens new window. Close the PubMed window to return to this page.)

Research Abstract

Infection with Epstein-Barr virus (EBV) is associated with a number of malignancies including endemic Burkitt's lymphoma (eBL), the most common childhood cancer in sub-Saharan Africa. The current research in my laboratory is directed towards three main areas of investigation. First, we have established a field research project based in Kisumu, Kenya to understand the how the interaction of co-factors including holoendemic malaria in the context of early primary infection with EBV lead to the emergence of eBL. Second, we are utilizing infection of mice with the murine gammaherpesvirus-68 (MHV-68) to examine early events in gammaherpesvirus pathogenesis as well as to model virus-parasite interactions. Finally, we are developing mechanism-based therapies for the treatment of BL and other AIDS-associated non-Hodgkin's lymphomas that address the unique needs in resource-poor settings using a preclincal model. In this preclinical model, SCID mice are engrafted with BL lines that have been in short-term culture and tagged with luciferase. We are using bioluminescent imaging to monitor tumor growth and response to treatment and to determine whether targeting of angiogenesis by adopting a metronomic schedule of therapy can induce remission and reduce toxicity.

Faculty Profile Shortcut:
Eric Wohlford

Eric Wohlford

Eric Wohlford received a 2012 travel award from the American Society of Tropical Medicine and Hygiene and spent two months in Kenya working in the lab of Rosemary Rochford, PhD, professor and chair of Upstate’s Department of Microbiology & Immunology. Eric studied the effects of malaria on B cells (producers of antibodies that fight infection) and Epstein-Barr Virus infection in the region. “Tropical medicine is unique, in that small, focused improvements in patient care make dramatic improvements in the well-being of patients,” he said.

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