The Dengue Research Center of Upstate Medical University is located in Weiskotten Hall. It is dedicated to improving the human condition through a variety of research methods including Dengue Vaccine and Viral Evolution in Rural Thailand.
Associate Professor and Chief of Infectious Disease, Department of Medicine Dr. Endy has extensive experience in dengue hemorrhagic fever and emerging diseases. His laboratory is currently developing an animal model for dengue hemorrhagic fever using humanized SCID mice.
Dr. Timothy Endy, MD, was awarded a research grant from the National Institute of General Medical Sciences for "Dengue Vaccine and Viral Evolution in Rural Thailand." With this funding, Dr. Endy will be part of an interdisciplinary university and military team of researchers in the US and Thailand that will conduct coordinated studies to determine the effect that vaccination with a candidate live-attenuated tetravalent vaccine will have on vaccine-related genetic changes on wild-type dengue virus and how these changes will determine risk for dengue hemorrhagic fever, a severe illness caused by the dengue virus that results in more than 20,000 deaths/year, virus transmission in the vaccinated and surrounding population, and its mosquito vector. The field testing of the first dengue vaccine efficacy study offers a unique opportunity to study the evolutionary consequences of this vaccine on wild-type dengue virus with findings that will have long-term impact on the design of future dengue vaccines and conduct of dengue vaccine efficacy trials.