Major Research Areas

Upstate boasts basic and clinical researchers with diverse expertise in neuroscience, molecular genetics, genomics, epigenetics, structural biology, infectious disease, and behavior disorders. This allows students the opportunity to perform research in a wide range of research areas and easily collaborate when new expertise is needed.

Dimitra Bourboulia, PhD

Dimitra Bourboulia, PhD
Appointed 08/19/13
3217 Weiskotten Hall
766 Irving Ave.
Syracuse, NY 13210

315 464-8712

Current Appointments

Hospital Campus

Research Programs and Affiliations

  • Biomedical Sciences Program
  • Urology

Education & Fellowships

  • Fellowship: National Cancer Institute, NIH, Bethesda, MD, 2013
  • Fellowship: University of London, UK, 2007
  • PhD: University of London, UK, 2004

Previous Appointments

  • National Institutes of Health, 2007–2013
  • University of London, UK, 1999–2007

Research Interests

  • * Extracellular signaling

    * Regulatory modifications in TIMPs and MMPs

    * Biological significance of extracellular protein phosphorylation in urological cancers

Associations/Memberships

  • American Association for Cancer Research (AACR)
  • American Urological Association (AUA)

Languages Spoken (Other Than English)

  • Greek

Publications

Link to PubMed External Icon (Opens new window. Close the PubMed window to return to this page.)

Research

Tumor cell growth and migration begin with the secretion of proteolytic enzymes that degrade the extracellular matrix (ECM) followed by an invasion of the tumor vasculature leading to initiation of metastasis. Matrix Metalloproteases (MMPs) and their endogenous inhibitors (TIMPs) are key components of extracellular proteolysis and regulators of the tumor microenvironment (TME). Identification of ways to inhibit early matrix proteolysis would enhance our ability to target early tumor development and prevent metastatic potential. Studies have suggested that MMP/TIMP balance is shifted towards MMP activation during cancer progression.

Our laboratory investigates molecular mechanisms of MMPs and TIMPs regulation in the extracellular space that impact homeostasis and cancer progression. Current research includes: (1) Post-translational regulation of TIMP-2 with focus on tyrosine phosphorylation, (2) Identification of novel TIMP-2 extracellular protein interactions involved in tumor cell migration and invasion, (3) Targeting extracellular signaling for the development of novel cancer therapeutics.

Faculty Profile Shortcut: http://www.upstate.edu/faculty/bourmpod