MSIV Schedule

MLC III: Current Biomedical Research (2010-2011)

Themes
Basic Science Reaches the Bedside: New Developments in Cancer Research
Personalized Medicine: The Dawn of a New Era
Controversies in Medicine: The Role of Evidence-Based Medicine





1: Basic Science Reaches the Bedside: New Developments in Cancer Research
July 27
Session #1: Nanotechnology

Background Material : Online Tutorial: Understanding Nanodevices
Research Paper: In-Vitro Characterization of a Targeted, Dye-Loaded Nanodevice for Intraoperative Tumor Delineation
1: Basic Science Reaches the Bedside: New Developments in Cancer Research
Aug 10
Session #2: Gene Chips

Background Material : Online Tutorial: Understanding Molecular Diagnostics
Research Paper: Gene Expression Profiling Assays in Early-Stage Breast Cancer
1: Basic Science Reaches the Bedside: New Developments in Cancer Research
Aug 24
Session #3: Vaccines

Background Materials :
Sipuleucel-T R&D Profile
Prostate Cancer Vaccines: Current Status and Future Potential
Research Paper:
Integrated Data from 2 Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trials of Active Cellular Immunotherapy with Sipuleucel-T in Advanced Prostate Cancer
1: Basic Science Reaches the Bedside: New Developments in Cancer Research
Sept 7
Session #4: SNPs

Background Material : Online Tutorial: Understanding SNPs and Cancer
Research Paper: Glutathione Pathway Genetic Polymorphisms and Lung Cancer Survival After Platinum-Based Chemotherapy
1: Basic Science Reaches the Bedside: New Developments in Cancer Research
Sept 21
Session #5: Receptors

Background Materials:
Erythropoietin Biology in Cancer
The Role of Erythropoietin and its Receptor in Growth, Survival and Therapeutic Response of Human Tumor Cells
Research Paper:
Effect of Treatment with Epoetin-Beta on Survival, Tumor Progression and Thromboembolic Patients with Cancer
2: Personalized Medicine: The Dawn of a New Era
Oct 5
Session #6: Genetics in Infectious Disease

Research Paper: CISH and Susceptibility to Infectious Diseases
2: Personalized Medicine: The Dawn of a New Era
Oct 19
Session #7: Genome-Wide Association Studies

Background Materials:
Failure to Validate Association between 12p13 Variants and Ischemic Stroke
Genomewide Association Studies and Human Disease
Genomewide Association Studies — Illuminating Biologic Pathways
Research Paper:
Genomewide Association Studies of Stroke
2: Personalized Medicine: The Dawn of a New Era
Nov 2
Session #8: Whole-Genome Sequencing

Background Material:
Individual Genomes on the Horizon
Research Paper:
Whole-Genome Sequencing in a Patient with Charcot–Marie–Tooth Neuropathy
2: Personalized Medicine: The Dawn of a New Era
Nov 16
Session #9: Pharmacogenetics

Background Materials:
Clopidogrel, Genetics, and Drug Responsiveness
Responding to the Clopidogrel Warning by the US Food and Drug Administration: Real Life Is Complicated
Research Paper:
Cytochrome P-450 Polymorphisms and Response to Clopidogrel
2: Personalized Medicine: The Dawn of a New Era
Nov 30
Session #10: Gene Therapy

Background Material:
Gene Therapy Fulfilling Its Promise
Ten Years of Gene Therapy for Primary Immune Deficiencies
Research Paper:
Gene Therapy for Immunodeficiency Due to Adenosine Deaminase Deficiency
3: Controversies in Medicine: The Role of Evidence-Based Medicine
Jan11
Session #11: Hormone Replacement Therapy

Research Papers:
Postmenopausal Estrogen and Porgestin Use and the Risk of Cardiovascular Disease
Estrogen plus Progestin and the Risk of Coronary Heart Disease
3: Controversies in Medicine: The Role of Evidence-Based Medicine
Jan 25
Session #12: Rise and Fall of Nesiritide

Background Material:
Nesiritide — Not Verified
Research Papers:
Intravenous Nesiritide, a Natriuretic Peptide, in the Treatment of Decompensated Congestive Heart Failure
Short-term Risk of Death After Treatment With Nesiritide for Decompensated Heart Failure
3: Controversies in Medicine: The Role of Evidence-Based Medicine
Feb 8
Session #13: Preeclampsia

Background Material:
Resolving Discrepancies Between a Meta-analysis and a Subsequent Large Controlled Trial
Research Papers:
Effect of Calcium Supplementation on Pregnancy-Induced Hypertension and Preeclampsia
Trial of Calcium to Prevent Preeclampsia
3: Controversies in Medicine: The Role of Evidence-Based Medicine
Feb 22
Session #14: Novel Treatments for Cholesterol

Background Material:
NCEP ATP III Guidelines
Research Papers:
MRC/BHF Heart Protection Study of Cholesterol Lowering with Simvastatin
Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
3: Controversies in Medicine: The Role of Evidence-Based Medicine
March 8
Session #15: Measuring Complex Interventions

Background Material:
Rapid Response Systems in Acute Hospital Care
5 Million Lives Campaign Getting Started Kit: Rapid Response Teams
Research Paper:
Introduction of the Medical Emergency Team (MET) System
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