MSIV Schedule

MLC III: Current Biomedical Research (2008-2009)

The main focus for each session is a report of clinical or translational research, oftentimes accompanied by a perspective piece (editorial, mini-review) and a report of some concrete event (patient case or news article) that makes the reason for studying the subject more obvious or compelling.

Jul
15
Hematology/Oncology: Cancer Treatment Breakthroughs -S. Grethlein

Perspective: Panitumumab the first fully human monoclonal antibody: from the bench to the clinic [Anti-Cancer Drugs 18: 7, 2007]
Trial: Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer [J Clin Oncol 26: 1626, 2008]
22
Neurosurgery: Deep Brain Stimulation - J. Holsapple

Perspective: Scientists Probe Deep Brain Stimulation [JAMA 298(19): 2249, 2007]
Study #1 : A Randomized Trial of Deep-Brain Stimulation for Parkinson’s Disease [NEJM 355(9): 896, 2006]
Study #2: Behavioural improvements with thalamic stimulation after severe traumatic brain injury [Nature 448: 600, 2007]
29
Infectious Disease/Global Health: Dengue Hemorrhagic Fever – T. Endy

Commentary: Dengue and Hemorrhagic Fever – A Potential Threat to Public Health in the United States [JAMA 299(2): 214, 2008]
Perspective: Hunt for Dengue Vaccine Heats Up As the Disease Burden Grows [Science 317: 1494, 2007]
Study: Epidemic Dengue and Dengue Hemorrhagic Fever at the Texas-Mexico Border: Results of a Household-based Seroepidemiologic Survey, December 2005 [Am J Trop Med Hyg 78(3): 364, 2008]
Aug
5
Cardiology: The Great Debate in Preventive Cardiology - R. Carhart

Research: Effect of Lower Targets for Blood Pressure and LDL Cholesterol on Atherosclerosis in Diabetes: The SANDS Randomized Trial [JAMA 299(14): 1678, 2008]
Editorial: The Great Debate of 2008—How Low to Go in Preventive Cardiology? [JAMA 299(14): 1718, 2008]
12
Transplant Surgery: Tolerance - A. Friedman

Research: HLA-Mismatched Renal Transplantation without Maintenance Immunosuppression [NEJM 358(4): 353, 2008]
Editorial: Immunosuppressive Therapy and Tolerance of Organ Allografts [NEJM 358(4): 407, 2008]
19
Surgery: Surgical Treatment of Type 2 Diabetes - P. Cunningham

Perspective: Is Type 2 Diabetes an Operable Intestinal Disease? [Diabetes Care 31(Suppl 2): S290, 2008]
Study: Adjustable Gastric Banding and Conventional Therapy for Type 2 Diabetes [JAMA 299(3):316, 2008]
Editorial: Gastrointestinal Surgery as a Treatment for Diabetes [JAMA 299(3): 341, 2008]

26
Family Medicine/Primary Care: Communicating Evidence to Patients – J. Epling

Editorial: Understanding Uncertainty [Ann Fam Med 6(3): 196, 2008]
Study 1: Absolute Cardiovascular Disease Risk and Shared Decision Making in Primary Care [Ann Fam Med 6(3): 218, 2008]
Study 2: Patients Prefer Pictures to Numbers to Express Cardiovascular Benefit From Treatment [Ann Fam Med 6(3): 213, 2008]
Sept
2
Emergency Medicine: Etomidate for Rapid-Sequence Intubation: Friend or Foe? - J. McCabe

Editorial: Should etomidate be used for rapid-sequence intubation induction in critically ill septic patients? [ Am J Emerg Med 26: 229, 2008]
Commentary: Clinical Controversies: Etomidate as an Induction Agent for Endotracheal Intubation in Patients With Sepsis [Ann Emerg Med 52(1): 13, 2008]
Study: Randomized Clinical Trial of Etomidate Versus Propofol for Procedural Sedation in the Emergency Department [Ann Emerg Med. 49: 15, 2007]
9
Medical Genetics: Mutations in Acute Myeloid Leukemia - R. Lebel

Editorial: Diagnosis and Prognosis in Acute Myeloid Leukemia - The Art of Distinction [NEJM 358(18): 1960, 2008]
Study:
Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia [NEJM 358(18): 1909, 2008]
16
Pediatrics/Nephrology: Controversy Regarding The Usage of Acyclovir Therapy in Neonates - T. Welch

Study: The Prevalence of Neonatal Herpes Simplex Virus Infection Compared with Serious Bacterial Illness in Hospitalized Neonates [ J Pediatr 153: 164, 2008]
Editorial #1: When Should You Initiate Acyclovir Therapy in a Neonate? [ J Pediatr 153: 155, 2008]
Editorial #2: In Defense of Empiric Acyclovir Therapy in Certain Neonates [J Pediatr 153: 157, 2008]
23
Psychiatry: Vagus Nerve Stimulation in the Treatment of Depression - T. Schwartz

Editorial: Approving the Vagus-Nerve Stimulator for Depression [NEJM 356(16): 1604]
Study 1: Vagus Nerve Stimulation for Treatment-Resistant Depression: A Randomized, Controlled Acute Phase Trial [Biol Psychiatry 58: 347]
Study 2: A One-Year Comparison of Vagus Nerve Stimulation with Treatment as Usual for Treatment-Resistant Depression [Biol Psychiatry 58: 364]
Oct
7
Public Health - Hepatitis A: Managing Foodborne Outbreaks - C. Morrow

Editorial: Hepatitis A – The Price of Progress [NEJM 353(9): 944, 2005]
Study: An Outbreak of Hepatitis A Associated with Green Onions [NEJM 353(9): 890, 2005]
Follow-up perspective: Universal Hepatitis A vaccination in the United States [Pediatr Infect Dis J 27(4): 287, 2008]
14
Pathology (session will originate from Binghamton Clinical Campus) – SIDS - J. Terzian

Perspective:
Sudden infant death syndrome [Lancet 370: 1578, 2007]
Study: Infant Death Scene Investigation and the Assessment of Potential Risk Factors for Asphyxia: A Review of 209 Sudden Unexpected Infant Deaths [J Forensic Sci 52(4): 924, 2007]
Follow-up study: Use of a Fan During Sleep and the Risk of Sudden Infant Death Syndrome [Arch Pediatr Adoles Med 162(10): 963, 2008)
21
Radiation OncologyLimits of Limited Stage Lymphoma - J. Bogart

Editorial: The Limits of Limited Stage Lymphoma [J Clin Oncol 22(15): 2982, 2004]
Study: Chemotherapy With or Without Radiotherapy in Limited-Stage Diffuse Aggressive Non-Hodgkin’s lymphoma: Eastern Cooperative Oncology Group Study 1484 [J Clin Oncol 22(15): 3032, 2004]
28
OB/GYN - Patient Choice in Delivery Method -L. Dutton

Perspective: ACOG Committee Opinion: Surgery and Patient Choice [American College of Obstetricians and Gynecologists Committee on Ethics, 39: 2008]
Review: Public Health Implications of Cesarean on Demand [Obstet Gynecol Surv 62(5): 323, 2007]
Perspective: Cesarean Delivery and the Risk–Benefit Calculus [NEJM 356(9): 885, 2007]
Nov
4
Surgery/Trauma - Blood Transfusions - J. Fortune

Study: A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care [NEJM 340(6): 409, 1999]
Study #2: Allogeneic blood transfusions explain increased mortality in women after coronary artery bypass graft surgery [Am Heart J 152:1028, 2006]
Perspective: Transfusion triggers [Surgery 142: S67, 2007]
11
Psychiatry – Borderline Personality Disorder - R. Gregory

Editorial: Psychotherapies and Lasting Change [Am J Psychiatry 165(5): 556, 2008]
Study: 8-Year Follow-Up of Patients Treated for Borderline Personality Disorder: Mentalization-Based Treatment Versus Treatment as Usual [Am J Psychiatry 165(5): 631, 2008]
18
ENT Balloon Sinuplasty - R. Kellman

Editorial:Balloon sinuplasty: A current hot topic in rhinology [Eur Arch Otorhinolaryngol 265: 509, 2008]
Study: Safety and outcomes of balloon catheter sinusotomy: A multicenter 24-week analysis in 115 patients [Otalaryngol Head Neck Surg 137(1): 10, 2007]
Dec
2
Neurology – ALS - J. Shefner

Editorial: Commentary on “A Novel, Efficient, Randomized Selection Trial Comparing Combinations of Drug Therapy for ALS [Amyotroph Lateral Scler 9: 254, 2008]
Case: Dan’s Story: Dan Maloney versus Amyotrophic Lateral Sclerosis
Study: A Novel, Efficient, Randomized Selection Trial Comparing Combinations of Drug Therapy for ALS [Amyotroph Lateral Scler 9: 212, 2008]
9
GastroenterologyBarrett's Esophagus - R. Szyjkowski

Study: Circumferential ablation of Barrett’s esophagus that contains high-grade dysplasia: A U.S. multicenter registry [Gastrointest Endosc 68: 35, 2008]
News Article : Esophageal Therapy You Can Stomach [Wall Street Journal, May 20, 2008]
Review: Medical Progress: Barrett’s Esophagus [NEJM 315(6): 362, 1986]
16
Nephrology - Genetics of IgA Nephrology - S. Scheinman

Study: Genome-wide linkage scan of a large family with IgA nephropathy localizes a novel susceptibility locus to chromosome 2q36 [J Am Soc Nephrol 18: 2408, 2007]
Review: Genetic studies of IgA nephropathy [Nephron Exp Nephrol 2006; 102: e76]
     
Jan
6
Hematology/Oncology - Graft Versus Host Disease - S. Grethlein

Perspective: Acute graft versus host disease [Orphanet J Rare Dis. 2:35, 2007]
Study:
Risk Factors for Acute Graft-Versus-Host Disease After Human Leukocyte Antigen–Identical Sibling Transplants for Adults With Leukemia [J Clin Oncol 26: 5728, 2008]
13
Clinical Pharmacology- Role of Pharmacogenomic Testing for Personalizing Medicine - D. Lehmann

Perspective:The Art and Science of Personalized Medicine [Clin Pharmacol Ther 2007; 81: 311]
Editorial: Pharmacogenomics and Drug Toxicity [NEJM 359(8): 856, 2008]
Study:
SLCO1B1 Variants and Statin-Induced Myopathy- A Genomewide Study [NEJM 359(8): 789, 2008]
20
Endocrinology - Vitamin D - A. Moses

Commentary: Vitamin D2 and Vitamin D3 Are They Equally Potent?
Study #1: Vitamin D2 Is as Effective as Vitamin D3 in Maintaining Circulating Concentrations of 25-Hydroxyvitamin D [J Clin Endocrinol Metab 93: 677–681, 2008]
Study #2:  Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2 [Am J Clin Nutr 68:854, 1998]
Study #3:
 Vitamin D2 Is Much Less Effective than Vitamin D3 in Humans [J Clin Endocrinol Metab 89: 5387, 2004]
27
Pediatrics (session will originate from Binghamton Clinical Campus) – Childhood Vaccinations - L. Lesperance

Study: Early Thimerosal Exposure and Neuropsychological Outcomes at 7 to 10 Years [NEJM 357(13): 1281, 2007]
Perspective: The Problem With Dr. Bob’s Alternative Vaccine Schedule [Pediatrics 123: e164: 2009]
Feb
3
Regenerative Medicine Bioengineered Blood Vessels - T. Poole

Perspective: Tissue Engineering: Where Are We Headed? [J Am Coll Surg 206(3): 1095, 2008]
Research:Bioengineered Three-Layered Robust and Elastic Artery Using Hemodynamically-Equivalent Pulsatile Bioreactor [Circulation 118(suppl 1): S52, 2008]
Commentary: Tissue-Engineered Blood Vessel for Adult Arterial Revascularization [NEJM 357(14): 1451, 2007]
10
Ophthalmology – Macular Degeneration - R. Barlow

Commentary: Evidence for an inflammatory process in age-related macular degeneration gains new support [Proc Natl Acad Sci U S A 102(20): 7053, 2005]
Research: Hypoglycemia leads to age-related loss of vision [Proc Natl Acad Sci U S A 103(51): 19541, 2006]
Research: A common haplotype in the complement regulatory gene factor H (HF1_CFH) predisposes individuals to age-related macular degeneration [Proc Natl Acad Sci U S A 102(20): 7227, 2005]
17
Dermatology - Phototherapy Treatment - R. Farah

Study: Photodynamic therapy with aminolevulinic acid topical solution and visible blue light in the treatment of multiple actinic keratoses of the face and scalp: investigator-blinded, phase 3, multicenter trials. [Arch Dermatol 140(1): 41, 2004]
Editorial: Photodynamic therapy for nonmelanoma skin cancer  - and more? [Arch Dermatol. 140(1): 116, 2004]
24
Microbiology/Global Health - Burkitt’s Lymphoma – R. Rochford

Perspective: Endemic Burkitt’s lymphoma: a polymicrobial disease? [Nat Rev Microbiol 3(2):182, 2005]
Study: Children with endemic Burkitt lymphoma are deficient in EBNA1-specific IFN-γ T cell responses [Int J Cancer 124:1721, 2009]
Mar
3
Urology - Pelvic Floor Disorders – F. Daneshgari

Study: The demographics of pelvic floor disorders: Current observations and future projections [Am J Obstet Gynecol 2001;184:1496-503]
Perspective: Open and unresolved clinical questions in female pelvic medicine and reconstructive surgery [BJU Int. 98(Suppl 1):110, 2006]
10
Orthopedic Surgery - Developmental Hip Dysplasia – D. Katz

Study: Intraarticular Findings in Symptomatic Developmental Dysplasia of the Hip [J Pediatr Orthop 29:9, 2009]
Perspective:
Developmental dysplasia of the hip: Definition, recognition, and prevention of late sequelae. [Ped Annals 35(2):92, 2006]
16
Global Health - Ethical Considerations in Global Health - A. Shaw

Perspective: Ethical Considerations for Short-term Experiences by Trainees in Global Health [JAMA 300(12): 1456, 2008]
Perspective: Living Apart Together: Reflections on Bioethics, Global Inequality and Social Justice [Philos Ethics Humanit Med 3:25, 2008]

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