MSII Schedule
MLC-II: Pathophysiology and Integrated Basic Sciences (2005-06) Case readings in BLUE, supplemental articles in ORANGE |
Aug | 29 | Introduction to course |
31 | Clear as Mud [NEJM 352(18): 1914, 2005] | |
Sept | 2 | Hypothesis Due |
7 | Case 13-1996 [NEJM 334(17):1116, 1996] | |
9 | Handout: Effects of endotoxin in humans | |
12 | Shock and multiple-organ dysfunction after self-administration of salmonella endotoxin [NEJM 328(20): 1457, 1993] | |
14 | ||
16 | Handout: Organ system dysfunction in sepsis | |
19 | Handout: Why sepsis trials fail | |
21 | Hypothesis Due | |
23 | Study Day | |
26 | Unit I Examination: Inflammation/hemodynamics | |
28 | A broken heart [NEJM 334(5): 319, 1996] | |
30 | Handout: Cardiac tamponade and pulsus paradoxus; Hypothesis Due | |
Oct | 3 | Through thick and thin [NEJM 338(23):1684, 1998] |
5 | ||
7 | Handout: Pathogenesis of pulmonary embolism; Hypothesis Due | |
12 | A leading question [NEJM 339(12): 827, 1998] | |
14 | Hypothesis Due | |
17 | The domino principle [NEJM 335(5): 340, 1996] | |
19 | Hypothesis Due | |
21 | Study Day | |
24 | Unit II Examination: Hematology/immunology | |
25 |
Anti-Ma 2 antibody related paraneoplastic limbic/brain stem encephalitis associated with breast cancer [J Neurol Neurosurg Psychiatry 74(9): 1332, 2003] | |
26 | Handout: Paraneoplastic limbic encaphalitis | |
28 | Shedding light on immunotherapy for cancer [NEJM 350(14): 1461, 2004]; Hypothesis Due | |
31 | Case 28-1997 [NEJM 337(11): 770, 1997] | |
Nov | 2 | A growing network of cancer-susceptibility genes [NEJM 348(19): 1917, 2003] |
4 | Hypothesis Due | |
7 |
A case of metastatic breast cancer with outgrowth of Her2-negative cells after eradication of Her2-positive cells byhumanized anti-Her2 monoclonal antibody (Trastuzumab) combined with docetaxel [Human Pathol 35(3):379, 2004] | |
9 |
Breast Cancer — Loss of PTEN Predicts Resistance to Treatment [NEJM 351(22): 2337, 2004 Handout: ACTR/AIB1 and Breast Cancer; Hypothesis Due |
|
11 |
Two metachronous tumors in the radiotherapy fields of a patient with Li-Fraumeni syndrome [Int J Cancer 96(4):238, 2001] Oncogenic pathways in hereditary and sporadic breast cancer [Maturitas 49:34, 2004]; Hypothesis Due |
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16 | Study Day | |
18 | Unit III Examination: Cancer | |
21 | Rituximab induces remission in refractory HCV associated cryoglobulinemic vasculitis [Ann Rheum Dis 62: 1230, 2003]; Handout: Biology of Hepatitis C virus | |
23 | Hypothesis Due | |
28 | A Perfect Storm [NEJM 353(18): 1956, 2005] | |
30 | ||
Dec | 2 | Hypothesis Due |
5 | Case 9-2004 [NEJM 350(12): 1236, 2004] | |
7 | Influenza virus still surprises [Curr Opin Microbiol 5: 414, 2002] | |
9 | Hypothesis Due | |
12 | Case 15-2005 [NEJM 352(20): 2111, 2005] | |
14 | Handout: Mechanisms of edema | |
16 | Handout: Amyloidosis; Hypothesis Due | |
21 | Unit IV Examination: Cardiovascular and pulmonary | |
Jan | 9 | Importance of a name [NEJM 340(18): 1418, 1999] |
11 | Mitochondrial dysfunction and Type 2 diabetes [Science 307: 384, 2005] Handout: Insulin Resistance |
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13 | Hypothesis Due | |
17 | Case 34-2000 [NEJM 343(19): 1399, 2000] | |
18 | ||
20 | Hypothesis Due | |
23 | A fractured diagnosis [NEJM 353(5): 509, 2005] | |
25 | Assignment: Renal involvement in connective tissue diseases and tubular syndromes | |
27 | Handout: Acid-Base; Hypothesis Due | |
30 | Case 4-2002 [NEJM 346(5): 353, 2002] | |
Feb | 1 | |
3 | Hypothesis Due | |
6 | Renal Review: Web Modules I | |
7 | Renal Review: Web Modules II | |
8 | Study Day | |
10 | Study Day | |
13 | Unit V Examination: Renal/Endocrine | |
14 | A girl with cystic fibrosis and failure to thrive [J Pediatr 143: 115, 2003] | |
15 | ||
17 | Handout: Normal and abnormal (Cystic Fibrosis) physiology; Hypothesis Due | |
20 | Clinical correlates of starvation in man [Mo Med 83(1): 23, 1986] | |
22 | Cachexia in Cancer - Zeroing in on Myosin [NEJM 351: 2124, 2004] Handout: Proteasome expression and resting energy expenditure |
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24 | Handout: Physiologic changes in normal pregnancy and in preeclampsia | |
27 | Case 30-1998 [NEJM 339(13): 906, 1998] | |
March | 1 | |
3 | Latest Advances in Understanding Preeclampsia [Science 308: 1592, 2005] Preeclampsia - Searching for the Cause [NEJM 350(7): 641, 2004]; Hypothesis Due |
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6 | Case 6-2001 [NEJM 344(8): 591, 2001] | |
8 | Assignment: MDMA interaction with neurotransmitter systems in CNS | |
10 | Handout: Mechanisms of liver injury; Hypothesis Due | |
13 | GI/Liver Review: Ulcerative colitis and Crohn’s disease | |
14 | GI/Liver Review: Case summaries | |
17 | Unit VI Examination: Gastroenterology/Gyn | |
27 | Case 5-2004 [NEJM 350(7): 707, 2004] | |
29 | Handout: Mechanisms of ischemia-reperfusion injury | |
31 |
Stroke and Neurovascular Protection [N Engl J Med 354: 553, 2006]; NXY-059 for Acute Ischemic Stroke [N Engl J Med 354: 588, 2006]; Handout: Toxic oxygen metabolics and proposed mechanism of free radical damage in stroke; Hypothesis Due | |
April | 3 | Comparing cognitive behavior therapy,interpersonal psychotherapy, &psychodynamic therapy [Am J Psychiatry 161:9, 2004] |
5 | ||
7 | Neurotrophic Effects of Electroconvulsive Therapy: A Proton Magnetic Resonance Study of the Left Amygdalar Region in Patients with Treatment-Resistant Depression [Neuropsychopharmacology (2003) 28, 720–725] | |
11 | A 48-year old man with temporal lobe epilepsy and psychiatric illness [JAMA 290(3): 381, 2003] | |
12 | ||
14 | ||
18 | Ventral occipital lesions impair object recognition but not object-directed grasping: an fMRI study [Brain 126(Pt 11):2463-75, 2003] | |
19 | ||
21 | ||
24 | Extra Credit Case | |
25 | Extra Credit Crossword | |
28 | Unit VII Examination: Neuro | |
May | 12 | Make-Up Quiz for Eligible Students |