MSII Schedule

MLC-II: Pathophysiology and Integrated Basic Sciences (2005-06)

Case readings in BLUE, supplemental articles in ORANGE
     
Aug 29 Introduction to course 
  31 Clear as Mud [NEJM 352(18): 1914, 2005]
Sept 2 Hypothesis Due
  7 Case 13-1996 [NEJM 334(17):1116, 1996] 
  9 Handout: Effects of endotoxin in humans
  12 Shock and multiple-organ dysfunction after self-administration of salmonella endotoxin [NEJM 328(20): 1457, 1993]
  14  
  16 Handout: Organ system dysfunction in sepsis
  19 Handout: Why sepsis trials fail 
  21 Hypothesis Due
  23 Study Day
  26 Unit I Examination: Inflammation/hemodynamics
  28 A broken heart [NEJM 334(5): 319, 1996]
  30 Handout: Cardiac tamponade and pulsus paradoxus; Hypothesis Due
Oct 3 Through thick and thin [NEJM 338(23):1684, 1998]
  5  
  7 Handout: Pathogenesis of pulmonary embolism; Hypothesis Due
  12 A leading question [NEJM 339(12): 827, 1998]
  14 Hypothesis Due
  17 The domino principle [NEJM 335(5): 340, 1996]
  19 Hypothesis Due
  21 Study Day
  24 Unit II Examination: Hematology/immunology
 

25

Anti-Ma 2 antibody related paraneoplastic limbic/brain stem encephalitis associated with breast cancer [J Neurol Neurosurg Psychiatry 74(9): 1332, 2003]       
  26 Handout: Paraneoplastic limbic encaphalitis
  28 Shedding light on immunotherapy for cancer [NEJM 350(14): 1461, 2004]; Hypothesis Due
  31 Case 28-1997 [NEJM 337(11): 770, 1997]
Nov 2 A growing network of cancer-susceptibility genes [NEJM 348(19): 1917, 2003]    
  4 Hypothesis Due
  7

A case of metastatic breast cancer with outgrowth of Her2-negative cells after eradication of Her2-positive cells byhumanized anti-Her2 monoclonal antibody (Trastuzumab) combined with docetaxel [Human Pathol 35(3):379, 2004]
  9

Breast Cancer — Loss of PTEN Predicts Resistance to Treatment [NEJM 351(22): 2337, 2004
Handout: ACTR/AIB1 and Breast Cancer; Hypothesis Due
  11

Two metachronous tumors in the radiotherapy fields of a patient with Li-Fraumeni syndrome [Int J Cancer 96(4):238, 2001]
Oncogenic pathways in hereditary and sporadic breast cancer [Maturitas 49:34, 2004]; Hypothesis Due
  16 Study Day
  18 Unit III Examination: Cancer
  21 Rituximab induces remission in refractory HCV associated cryoglobulinemic vasculitis [Ann Rheum Dis 62: 1230, 2003]; Handout: Biology of Hepatitis C virus
  23 Hypothesis Due
  28 A Perfect Storm [NEJM 353(18): 1956, 2005]
  30  
Dec 2 Hypothesis Due
  5 Case 9-2004 [NEJM 350(12): 1236, 2004]
  7 Influenza virus still surprises [Curr Opin Microbiol 5: 414, 2002]
  9 Hypothesis Due
  12 Case 15-2005 [NEJM 352(20): 2111, 2005]
  14 Handout: Mechanisms of edema
  16 Handout: Amyloidosis; Hypothesis Due
  21 Unit IV Examination: Cardiovascular and pulmonary
     
Jan 9 Importance of a name [NEJM 340(18): 1418, 1999]
  11 Mitochondrial dysfunction and Type 2 diabetes [Science 307: 384, 2005]
Handout: Insulin Resistance
  13 Hypothesis Due
  17 Case 34-2000 [NEJM 343(19): 1399, 2000]
  18  
  20 Hypothesis Due
  23 A fractured diagnosis [NEJM 353(5): 509, 2005]
  25 Assignment: Renal involvement in connective tissue diseases and tubular syndromes
  27 Handout: Acid-Base; Hypothesis Due
  30 Case 4-2002 [NEJM 346(5): 353, 2002]
Feb 1  
  3 Hypothesis Due
  6 Renal Review: Web Modules I
  7 Renal Review: Web Modules II
  8 Study Day
  10 Study Day
  13 Unit V Examination: Renal/Endocrine
  14 A girl with cystic fibrosis and failure to thrive [J Pediatr 143: 115, 2003]
  15  
  17 Handout: Normal and abnormal (Cystic Fibrosis) physiology; Hypothesis Due
  20 Clinical correlates of starvation in man [Mo Med 83(1): 23, 1986]
  22 Cachexia in Cancer - Zeroing in on Myosin [NEJM 351: 2124, 2004]
Handout: Proteasome expression and resting energy expenditure
  24 Handout: Physiologic changes in normal pregnancy and in preeclampsia
  27 Case 30-1998 [NEJM 339(13): 906, 1998]
March 1  
  3 Latest Advances in Understanding Preeclampsia [Science 308: 1592, 2005]
Preeclampsia - Searching for the Cause [NEJM 350(7): 641, 2004]; Hypothesis Due
  6 Case 6-2001 [NEJM 344(8): 591, 2001]
  8 Assignment: MDMA interaction with neurotransmitter systems in CNS
  10 Handout: Mechanisms of liver injury; Hypothesis Due
  13 GI/Liver Review: Ulcerative colitis and Crohn’s disease
  14 GI/Liver Review: Case summaries
  17 Unit VI Examination: Gastroenterology/Gyn
  27 Case 5-2004 [NEJM 350(7): 707, 2004]
  29 Handout: Mechanisms of ischemia-reperfusion injury
  31

Stroke and Neurovascular Protection [N Engl J Med 354: 553, 2006]; NXY-059 for Acute Ischemic Stroke [N Engl J Med 354: 588, 2006]; Handout: Toxic oxygen metabolics and proposed mechanism of free radical damage in stroke; Hypothesis Due
April 3 Comparing cognitive behavior therapy,interpersonal psychotherapy, &psychodynamic therapy [Am J Psychiatry 161:9, 2004]
  5  
  7 Neurotrophic Effects of Electroconvulsive Therapy: A Proton Magnetic Resonance Study of the Left Amygdalar Region in Patients with Treatment-Resistant Depression [Neuropsychopharmacology (2003) 28, 720–725]
  11 A 48-year old man with temporal lobe epilepsy and psychiatric illness [JAMA 290(3): 381, 2003]
  12  
  14  
  18 Ventral occipital lesions impair object recognition but not object-directed grasping: an fMRI study [Brain 126(Pt 11):2463-75, 2003]
  19  
  21  
  24 Extra Credit Case
  25 Extra Credit Crossword
  28 Unit VII Examination: Neuro
May 12 Make-Up Quiz for Eligible Students 


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