Major Research Areas

Researchers in the College of Graduate Studies focus their efforts where it truly matters—on the diseases and illnesses that affect many people. Much of our research activity is grouped into four areas of concentration: cancer; infectious diseases; disorders of the nervous system; and diabetes, metabolic disorders and cardiovascular diseases.

Joseph B Domachowske, MD

Joseph B Domachowske, MD
Appointed 06/26/89
5400 Upstate University Hospital - Downtown Campus
750 East Adams Street
Syracuse, NY 13210

315 464-6331

Current Appointments

Hospital Campus

  • Downtown

Clinical Section Affiliations

  • Pediatrics: Infectious Disease

Research Programs and Affiliations

  • Biomedical Sciences Program
  • Pediatrics
  • Research Pillars


Education & Fellowships

  • Fellowship: National Intsitutes of Health, Laboratory of Host Defenses, 1997
  • Residency: SUNY Health Science Center at Syracuse, 1992
  • MD: SUNY Health Science Center at Syracuse, 1989

Clinical Interests

  • Pediatric infectious diseases

Research Interests

  • Pneumovirus pathogenesis.

Clinical Trials

  • A phase 1b/2a randomized, double-blind, placebo-controlled, dose-escalation study to evaluate the safety, tolerability, and pharmacokinetics of MEDI8897, a monoclonal antibody with an extended half-life against respiratory syncytial virus, in healthy preterm infants
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  • A prospective, epidemiological study to assess the disease burden of respiratory syncytial virus (RSV) associated, suspected lower respiratory tract infections (LRTIs) in newborns, from birth up to 2 years of age.
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  • A single-center in vitro study to evaluate GSK 1325756 inhibition of CD11b cell surface expression in healthy adults and respiratory syncytial virus-infected children <2 years
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  • An Epidemiologic Study of Pregnant Women and their Newborn Infants to Describe Immune Status and Respiratory Syncytial Virus and Cytomegalovirus Infection Rates
    Read more
  • An observer-blind study to assess the safety, reactogenicity and immunogenicity of different formulations of GSK Biologicals’ investigational RSV vaccine (GSK3003891A), in healthy women
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  • Immunogenicity and safety study of GSK Biologicals’ quadrivalent influenza vaccine (GSK2282512A) compared to Fluzone® Quadrivalent in children 6 to 35 months of age. 201234 (FLU-Q-QIV-022)
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  • The SENTINEL 1 Study: An Observational, Non-Interventional Study in the United States to Characterize Respiratory Syncytial Virus Hospitalizations among Infants Born at 29 to 35 Weeks Gestational Age Not Receiving Immunoprophylaxis
    Read more

Specialties & Certification

  • Pediatrics
  • Pediatric Infectious Diseases

Diseases & Conditions Treated

  • Antibiotic-Associated Diarrhea
  • Antibiotic-Resistant Infections
  • Bacterial Meningitis in Children
  • Fever
  • Giardiasis
  • HIV Infection and AIDS
  • Herpes Encephalitis
  • Immune Abnormalities
  • Infections of Bones and Joints
  • Infectious Mononucleosis
  • Infective Endocarditis
  • Pneumonia
  • Shingles
  • Tuberculosis (TB)
  • Viral Infections in Children
  • Viral Meningitis in Children
  • Yeast Infection or Candidiasis


  • Children


  • Infectious Diseases Society of America (IDSA)
  • American Academy of Pediatrics

Current Hospital Privileges

  • Upstate University Hospital

HealthLinkOnAir Radio Interview

10/6/13 Improving immunization rates in low-income populations

7/25/13 The growing incidence of HPV and its connection to oral sex

8/19/12 Whooping cough cases are on the rise

5/6/12 Antibiotic resistance


Link to PubMed External Icon (Opens new window. Close the PubMed window to return to this page.)


My laboratory program focuses on the molecular interactions between pneumoviruses and pulmonary epithelium. Short term goals include understanding the mechanisms of virus-induced alterations in epithelial cell gene expression. Longer term goals include developing and characterizing specific anti-viral and anti-inflammatory interventions for the treatment of viral bronchiolitis. We study these interactions in vitro, using tissue culture models, and in vivo using our rodent model of pneumovirus infection. Recently, we have also been successful in demonstrating the physiologic significance of results from our model systems in samples obtained from human infants with severe respiratory syncytial virus bronchiolitis.
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