Dimitra Bourboulia, PhD

Dimitra Bourboulia, PhD
Appointed 08/19/13
4251 Weiskotten Hall
766 Irving Ave.
Syracuse, NY 13210

315 464-8712

Current Appointments

Hospital Campus

Research Programs and Affiliations

  • Biomedical Sciences Program
  • Research Pillars
  • Urology

Education & Fellowships

  • Fellowship: National Cancer Institute, NIH, Bethesda, MD, 2013
  • Fellowship: University of London, UK, 2007
  • PhD: University of London, UK, 2004

Previous Appointments

  • National Institutes of Health, 2007–2013
  • University of London, UK, 1999–2007

Research Interests

  • * Cancer Biology and Cell Signaling

    * Molecular mechanisms of tumor invasion and metastasis 

    * Prostate cancer development and progression

Languages Spoken (Other Than English)

  • Greek


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Research Abstract

Matrix Metalloproteases (MMP) are involved in tumor angiogenesis, invasion and metastasis. MMP are inhibited by a family of endogenous proteins, the Tissue Inhibitor of Metalloproteases or TIMPs. TIMP-2 is not only a natural occurring inhibitor of MMP, but also an inhibitor of tumor cell growth, migration, invasion and tumor angiogenesis, independently of MMP inhibitory activity.


Studies have suggested that MMP/TIMP balance is shifted towards MMP activation during cancer progression and metastasis. In addition, epigenetic inactivation of TIMP-2 promoter, i.e. hypermethylation, occurs in several cancers including prostate tumors leading to downregulation of TIMP-2 levels. It is, therefore, essential to determine how TIMP-2 is regulated, to mechanistically understand the tumor inhibitory effects. My current studies are focused on TIMP-2 post-translational regulation and how this regulation affects TIMP-2 anti-tumoral and anti-angiogenic properties in epithelial cancers, and in particular, urological malignancies. 

Faculty Profile Shortcut: http://www.upstate.edu/faculty/bourmpod
Sue Stearns in anatomy lab

Sue Stearns, PhD, is an associate professor of cell and developmental biology, and one of four faculty members who teach Gross Anatomy to first-year medical students at SUNY Upstate. Students routinely cite this course as a favorite.

Read more about Stearns' take on our Anatomy course's popularity.