RESEARCH PROFILE
original: wild-type paxillin cells
rollover: paxillin lacking LD4 cells

These cells were scratch-wounded followed by fixation 12-hours post-wounding. Tubulin (Green) and alpha-mannosidase II (Red) were labeled to note cell polarization and Golgi orientation. Cells expressing paxillin lacking LD4 are unable to reorient the Golgi towards the wound edge. From the lab of Christopher Turner, PhD.

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Recent Publications

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Myosin 1e is a component of the invadosome core that contributes to regulation of invadosome dynamics. External Icon
Ouderkirk JL, Krendel M.
Exp Cell Res. 2014 Apr 1;322(2):265-76.

Visualization of cytoskeletal dynamics in podocytes using adenoviral vectors. External Icon
Bi J, Pellenz CD, Krendel M.
Cytoskeleton. 2014 Mar;71(3):145-56.

Myosin 1e is a component of the glomerular slit diaphragm complex that regulates actin reorganization during cell-cell contact formation in podocytes. External Icon
Bi J, Chase SE, Pellenz CD, Kurihara H, Fanning AS, Krendel M.
Am J Physiol Renal Physiol. 2013 Aug 15;305(4):F532-44.

Podocyte-specific knockout of myosin 1e disrupts glomerular filtration. External Icon
Chase SE, Encina CV, Stolzenburg LR, Tatum AH, Holzman LB, Krendel M.
Am J Physiol Renal Physiol. 2012 Oct;303(7):F1099-106.

MYO1E Mutations and Childhood Familial Focal Segmental Glomerulosclerosis. External Icon
Mele C, Iatropoulos P, Donadelli R, Calabria A, Maranta R, Cassis P, Buelli S, Tomasoni S, Piras R, Krendel M, Bettoni S, Morigi M, Delledonne M, Pecoraro C, Abbate I, Capobianchi MR, Hildebrandt F, Otto E, Schaefer F, Macciardi F, Ozaltin F, Emre S, Ibsirlioglu T, Benigni A, Remuzzi G, Noris M. N Engl J Med. 2011 Jul 28;365(4):295-306.

Myo1e binds anionic phospholipids with high affinity. External Icon
E.A. Feeser, C.M. Ignacio, M. Krendel, and E.M. Ostap. Biochemistry, 49:9353-60, 2010.

Disruption of Myosin 1e promotes podocyte injury. External Icon
M. Krendel, S.V.Kim, T. Willinger, T. Wang, M. Kashgarian, R.A. Flavell, and M.S. Mooseker. JASN, 20:86-94, 2009.