Recent Publications

Myosin 1e is a component of the glomerular slit diaphragm complex that regulates actin reorganization during cell-cell contact formation in podocytes.
Bi J, Chase SE, Pellenz CD, Kurihara H, Fanning AS, Krendel M.
Am J Physiol Renal Physiol. 2013 Aug 15;305(4):F532-44.

Podocyte-specific knockout of myosin 1e disrupts glomerular filtration.
Chase SE, Encina CV, Stolzenburg LR, Tatum AH, Holzman LB, Krendel M.
Am J Physiol Renal Physiol. 2012 Oct;303(7):F1099-106.

MYO1E Mutations and Childhood Familial Focal Segmental Glomerulosclerosis.
Mele C, Iatropoulos P, Donadelli R, Calabria A, Maranta R, Cassis P, Buelli S, Tomasoni S, Piras R, Krendel M, Bettoni S, Morigi M, Delledonne M, Pecoraro C, Abbate I, Capobianchi MR, Hildebrandt F, Otto E, Schaefer F, Macciardi F, Ozaltin F, Emre S, Ibsirlioglu T, Benigni A, Remuzzi G, Noris M. N Engl J Med. 2011.

Myo1e binds anionic phospholipids with high affinity.
E.A. Feeser, C.M. Ignacio, M. Krendel, and E.M. Ostap. Biochemistry, 49:9353-60, 2010.

Disruption of Myosin 1e promotes podocyte injury.
M. Krendel, S.V.Kim, T. Willinger, T. Wang, M. Kashgarian, R.A. Flavell, and M.S. Mooseker. JASN, 20:86-94, 2009.

Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis.
M. Krendel, E.K. Osterweil, and M.S. Mooseker. FEBS Lett., 581:644-50, 2007.

Myosins: tails (and heads) of functional diversity.
M. Krendel, M.S. Mooseker. Physiology, 20:239-51, 2005.

p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor.
F.T. Zenke, M. Krendel, C. DerMardirossian, C.C. King, B.P. Bohl, G.M. Bokoch. J. Biol. Chem. 279: 18392-400, 2004.

Nucleotide exchange factor GEF-H1 mediates cross-talk between microtubules and the actin cytoskeleton.
M. Krendel, F.T. Zenke, G.M. Bokoch. Nature Cell Biology, 4:294-301, 2002.

Book Chapters

M. Krendel and E.M. De La Cruz. Actin Binding Protein Function and its Relation to Disease Pathology. In Actin-Binding Proteins and Disease, Dos Remedios and Chhabra (Eds.), Springer, 2007.

J.K. Au, M. Krendel, D. Safer, and E.M. De La Cruz. The Roles of Thymosin beta4 in Cell Migration and Cell-to-Cell Signaling in Disease. In Actin-Binding Proteins and Disease, Dos Remedios and Chhabra (Eds.), Springer, 2007.