These cells were scratch-wounded followed by fixation 12-hours post-wounding. Tubulin (Green) and alpha-mannosidase II (Red) were labeled to note cell polarization and Golgi orientation. Cells expressing paxillin lacking LD4 are unable to reorient the Golgi towards the wound edge. From the lab of Christopher Turner, PhD.
Welcome to the Krendel Lab in the Department of Cell and Developmental Biology at SUNY Upstate Medical University.
Our lab studies physiological functions of myosin motors that move various cargoes along actin filaments. Ongoing projects in the lab include analysis of the role of myosin motors in endocytosis, contribution of myosins to kidney functions, and the role of myosins in regulation of cell migration and adhesion. These studies are aimed at elucidating the roles of myosins in human health and disease, including cancer, diabetes, and chronic kidney disease. For more information, visit the Research page.
Experimental approaches used in our lab include live cell imaging, adenovirus-mediated protein expression and knockdown, transgenic mouse studies, and protein-protein interaction assays.