These cells were scratch-wounded followed by fixation 12-hours post-wounding. Tubulin (Green) and alpha-mannosidase II (Red) were labeled to note cell polarization and Golgi orientation. Cells expressing paxillin lacking LD4 are unable to reorient the Golgi towards the wound edge. From the lab of Christopher Turner, PhD.
Program Director/Department Chair: Joseph Sanger, PhD
Genetics and cell biology of organ morphogenesis during embryonic development.
Actin Cytoskeletal Dynamics in the leukocyte inflammatory phenotype.
Physiological functions of myosin motors and their roles in diabetic kidney disease and cancer
Regulation of ciliary dynein activity and assembly, and the role of the central pair complex in ciliary motility regulation.
Biology of oligodendroglia and myelin formation during development, remyelination and repair in spinal cord injury and MS
Vascular development and the alignment of growing nerves and blood vessels in quail and zebrafish embryos.
Biochemistry and cell biology of formins as actin cytoskeleton organizers, using Caenorhabditis elegans as a model system.
Analysis of the assembly of the actin/myosin cytoskeleton in muscle and non-muscle cells.
Cellular analysis of the formation of myofibrils, stress fibers, and cleavage furrows in living cells.
Mechanisms of the actin cytoskeleton assembly and role of myosin-1 during endocytosis in fission yeast.
Regulation of cell migration by focal adhesion adapter proteins and their role in cancer cell metastasis.